Imidazolopyrazinones as potential antioxidants

被引：35

作者：

Devillers, I

Dive, G

De Tollenaere, C

Falmagne, B

de Wergifosse, B

Rees, JF

Marchand-Brynaert, J

机构：

[1] Univ Catholique Louvain, Unite Chim Organ & Med, B-1348 Louvain, Belgium

[2] Univ Catholique Louvain, Unite Biol Anim, B-1348 Louvain, Belgium

[3] Univ Liege, Ctr Ingn Prot, B-4000 Liege, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)00445-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of imidazolopyrazinones 3, substituted at C-2, and C-2/C-6, has been prepared. The compounds behaved as quenchers of superoxide anion. The more active compounds are structurally related to coelenterazine, a natural substrate of marine bioluminescence. Theoretical parameters based on Hartree-Fock instabilities hake been examined. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2305 / 2309

页数：5

共 42 条

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