Predictable and unpredictable evolution of antibiotic resistance

被引：82

作者：

Courvalin, P. ^{[1
]}

机构：

[1] Inst Pasteur, Unite Agents Antibacteriens, F-75724 Paris 15, France

来源：

JOURNAL OF INTERNAL MEDICINE | 2008年 / 264卷 / 01期

关键词：

antibiotic; biological cost; evolution; insertion sequence; mutation; resistance; transposon;

D O I：

10.1111/j.1365-2796.2008.01940.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evolution of bacteria towards antibiotic resistance is unavoidable as it represents a particular aspect of the general evolution of bacteria. Thus, at the very best, the only hope we can have in the field of resistance is to delay dissemination of resistant bacteria or resistance genes. Resistance to antibiotics in bacteria can result from mutations in resident structural or regulatory genes or from horizontal acquisition of foreign genetic information. In this review, we will consider the predictable future of the relationship between bacteria and antibiotics.

引用

页码：4 / 16

页数：13

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