Predictable and unpredictable evolution of antibiotic resistance

被引：82

作者：

Courvalin, P. ^{[1
]}

机构：

[1] Inst Pasteur, Unite Agents Antibacteriens, F-75724 Paris 15, France

来源：

JOURNAL OF INTERNAL MEDICINE | 2008年 / 264卷 / 01期

关键词：

antibiotic; biological cost; evolution; insertion sequence; mutation; resistance; transposon;

D O I：

10.1111/j.1365-2796.2008.01940.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evolution of bacteria towards antibiotic resistance is unavoidable as it represents a particular aspect of the general evolution of bacteria. Thus, at the very best, the only hope we can have in the field of resistance is to delay dissemination of resistant bacteria or resistance genes. Resistance to antibiotics in bacteria can result from mutations in resident structural or regulatory genes or from horizontal acquisition of foreign genetic information. In this review, we will consider the predictable future of the relationship between bacteria and antibiotics.

引用

页码：4 / 16

页数：13

共 36 条

[21] Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: a randomised, double-blind, placebo-controlled study [J].

Malhotra-Kumar, Surbhi ;

Lammens, Christine ;

Coenen, Samuel ;

Van Herck, Koen ;

Goossens, Herman .

LANCET, 2007, 369 (9560) :482-490

[22] D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB [J].

Marshall, CG ;

Broadhead, G ;

Leskiw, BK ;

Wright, GD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (12) :6480-6483

[23] Integrons: agents of bacterial evolution [J].

Mazel, Didier .

NATURE REVIEWS MICROBIOLOGY, 2006, 4 (08) :608-620

[24] GENE-TRANSFER BETWEEN DISTANTLY RELATED BACTERIA [J].

MAZODIER, P ;

DAVIES, J .

ANNUAL REVIEW OF GENETICS, 1991, 25 :147-171

[25] Multiple antibiotic resistance gene transfer from animal to human enterococci in the digestive tract of gnotobiotic mice [J].

Moubareck, C ;

Bourgeois, N ;

Courvalin, P ;

Doucet-Populaire, F .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (09) :2993-2996

[26] High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection [J].

Oliver, A ;

Cantón, R ;

Campo, P ;

Baquero, F ;

Blázquez, J .

SCIENCE, 2000, 288 (5469) :1251-1253

[27] Transferable resistance to aminoglycosides by methylation of G1405 in 16S rRNA and to hydrophilic fluoroquinolones by QepA-mediated efflux in Escherichia coli [J].

Perichon, Bruno ;

Courvalin, Patrice ;

Galimand, Marc .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (07) :2464-2469

[28] β-Lactamases:: Protein evolution in real time [J].

Petrosino, J ;

Cantu, C ;

Palzkill, T .

TRENDS IN MICROBIOLOGY, 1998, 6 (08) :323-327

[29] Efflux-mediated multiresistance in Gram-negative bacteria [J].

Poole, K .

CLINICAL MICROBIOLOGY AND INFECTION, 2004, 10 (01) :12-26

[30] Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae [J].

Prudhomme, Marc ;

Attaiech, Laetitia ;

Sanchez, Guillaume ;

Martin, Bernard ;

Claverys, Jean-Pierre .

SCIENCE, 2006, 313 (5783) :89-92

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