Immuno-polymeric nanoparticles by Diels-Alder chemistry

被引：101

作者：

Shi, Meng

Wosnick, Jordan H.

Ho, Karyn

Keating, Armand

Shoichet, Molly S.

机构：

[1] Terrence Donnlly Ctr Cellular & Biomol REs, Inst Biomat & Biomed Engn, Dept Chem, Dept Chem Engn & Appl Chem, Toronto, ON M5S 3E1, Canada

[2] Univ Hlth Network, Princess Margaret Hosp, Ontario Canc Inst, Toronto, ON, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 32期

关键词：

bioorganic chemistry; cycloaddition; drug delivery; micelles; self-assembly;

D O I：

10.1002/anie.200701032

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Hitting the target: Self-assembled polymeric nanoparticles from an amphiphilic copolymer were prepared with furan groups on the outer polyethylene glycol corona that were accessible for Diels-Alder reactions with maleimide-functionalized antibodies for the preparation of immuno-nanoparticles (see picture). The simple and clean coupling methodology allows facile modification of nanoparticles for use in targeted delivery to cancer cells. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6126 / 6131

页数：6

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