Application of autologous bone marrow stem cells in the therapy of spinal cord injury patients

被引:76
作者
Chernykh, E. R. [1 ]
Stupak, V. V.
Muradov, G. M.
Sizikov, M. Yu.
Shevela, E. Ya.
Leplina, O. Yu.
Tikhonova, M. A.
Kulagin, A. D.
Lisukov, I. A.
Ostanin, A. A.
Kozlov, V. A.
机构
[1] Russian Acad Med Sci, Siberian Div, Inst Clin Immunol, Moscow 109801, Russia
[2] Inst Traumatol & Orthopedy, Novosibirsk, Russia
关键词
spinal cord injury; stem cells; bone marrow; transplantation;
D O I
10.1007/s10517-007-0175-y
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
We studied the safety and efficiency of transplantation of autologous bone marrow cells in complex therapy of patients with spinal cord injury in the late period of the disease. In control group patients, meningomyeloradiculolis was performed, while in the main group surgical treatment was supplemented by transplantation of autologous bone marrow cells. Transplantation of BM stem cells into the cyst cavity and intravenously was well tolerated, did not cause allergic or inflammatory reactions in the early and delayed periods after surgery, and did not induce the formation of ossification foci in the nervous tissue. Analysis of the neurological status by ASIA, Bartel, and Ashworth scales showed that in the main group the positive clinical dynamics was more often observed than in the control. The decrease in neurological deficit included improvement of sensory and motor activity and conducting sensory function. Thus, transplantation of autologous bone marrow cells can be a novel safe strategy for the treatment of patients in the late period after spinal trauma.
引用
收藏
页码:543 / 547
页数:5
相关论文
共 15 条
[1]   Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in national Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III [J].
Bracken, MB ;
Holford, TR .
JOURNAL OF NEUROSURGERY, 2002, 96 (03) :259-266
[2]   Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats [J].
Chen, JL ;
Sanberg, PR ;
Li, Y ;
Wang, L ;
Lu, M ;
Willing, AE ;
Sanchez-Ramos, J ;
Chopp, M .
STROKE, 2001, 32 (11) :2682-2688
[3]  
CHERNYKH EP, 2006, KLETOCHN TEKHNOL BIO, P8
[4]   Spinal cord injury in rat: treatment with bone marrow stromal cell transplantation [J].
Chopp, M ;
Zhang, XH ;
Li, Y ;
Wang, L ;
Chen, JL ;
Lu, DY ;
Lu, M ;
Rosenblum, M .
NEUROREPORT, 2000, 11 (13) :3001-3005
[5]  
Corti S., 2003, Current Gene Therapy, V3, P247, DOI 10.2174/1566523034578375
[6]   Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery [J].
Hofstetter, CP ;
Schwarz, EJ ;
Hess, D ;
Widenfalk, J ;
El Manira, A ;
Prockop, DJ ;
Olson, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2199-2204
[7]   Recent advances in pathophysiology and treatment of spinal cord injury [J].
Hulsebosch, CE .
ADVANCES IN PHYSIOLOGY EDUCATION, 2002, 26 (04) :238-255
[8]   Adult stem cells for tissue repair - A new therapeutic concept? [J].
Korbling, M ;
Estrov, Z .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (06) :570-582
[9]  
KOSICHKIN MA, 1999, MED SOCIAL EXAMINATI
[10]   Treatment of complete spinal cord injury patients by autologous bone marrow cell transplantation and administration of granulocyte-macrophage colony stimulating factor [J].
Park, HC ;
Shim, YS ;
Ha, Y ;
Yoon, SH ;
Park, SR ;
Choi, BH ;
Park, HS .
TISSUE ENGINEERING, 2005, 11 (5-6) :913-922