Asymmetric hydrosilylation of aryl ketones catalyzed by copper hydride complexed by nonracemic biphenyl bis-phosphine ligands

被引：241

作者：

Lipshutz, BH ^{[1
]}

Noson, K ^{[1
]}

Chrisman, W ^{[1
]}

Lower, A ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 29期

关键词：

D O I：

10.1021/ja021391f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

When complexed by selected ligands in either the BIPHEP or the SEGPHOS series, CuH is an extremely reactive catalyst capable of effecting asymmetric hydrosilylations of aromatic ketones at temperatures between -50 and -78degreesC. Inexpensive silanes serve as stoichiometric sources of hydride. Substrate-to-ligand ratios exceeding 100,000: 1 have been documented. The level of induction is usually in the > 90% ee category. The nature of the reagent has been investigated using spectroscopic and chemical means, although its composition remains unclear.

引用

页码：8779 / 8789

页数：11

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