Mesenchymal stem cell-derived factors: Immuno-modulatory effects and therapeutic potential

被引：208

作者：

Volarevic, Vladislav ^{[1
]}

Gazdic, Marina ^{[2
]}

Markovic, Bojana Simovic ^{[1
]}

Jovicic, Nemanja ^{[3
]}

Djonov, Valentin ^{[4
]}

Arsenijevic, Nebojsa ^{[1
]}

机构：

[1] Univ Kragujevac, Dept Microbiol & Immunol, Ctr Mol Med & Stem Cell Res, Fac Med Sci, Kragujevac, Serbia

[2] Univ Kragujevac, Dept Genet, Fac Med Sci, Kragujevac, Serbia

[3] Univ Kragujevac, Dept Histol & Embryol, Fac Med Sci, Kragujevac, Serbia

[4] Univ Bern, Inst Anat, Dept Topog & Clin Anat, Bern, Switzerland

来源：

BIOFACTORS | 2017年 / 43卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

mesenchymal stem cells; immune response; soluble factors; inflammation; immune-mediated diseases; UMBILICAL-CORD BLOOD; REGULATORY T-CELLS; BONE-MARROW; STROMAL CELLS; TGF-BETA; CROHNS-DISEASE; PERIANAL FISTULAS; ADIPOSE-TISSUE; INDOLEAMINE 2,3-DIOXYGENASE; MULTIPLE-SCLEROSIS;

D O I：

10.1002/biof.1374

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

. Stem cell-based therapy is considered to be a new hope in transplantation medicine. Among stem cells, mesenchymal stem cells (MSCs) are, due to their differentiation and immuno-modulatory characteristics, the most commonly used as therapeutic agents in the treatment of immune-mediated diseases. MSCs migrate to the site of inflammation and modulate immune response. The capacity of MSC to alter phenotype and function of immune cells are largely due to the production of soluble factors which expression varies depending on the pathologic condition to which MSCs are exposed. Under inflammatory conditions, MSCs-derived factors suppress both innate and adaptive immunity by attenuating maturation and capacity for antigen presentation of dendritic cells, by inducing polarization of macrophages towards alternative phenotype, by inhibiting activation and proliferation of T and B lymphocytes and by reducing cytotoxicity of NK and NKT cells. In this review, we emphasized current findings regarding immuno-modulatory effects of MSC-derived factors and emphasize their potential in the therapy of immune-mediated diseases. (c) 2017 BioFactors, 43(5):633-644, 2017

引用

页码：633 / 644

页数：12

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