Regulation of differentiation by TGF-beta

被引：189

作者：

Moses, HL ^{[1
]}

Serra, R ^{[1
]}

机构：

[1] VANDERBILT UNIV,MED CTR,DEPT CELL BIOL,NASHVILLE,TN 37232

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 05期

关键词：

D O I：

10.1016/S0959-437X(96)80087-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent experiments in neural, skeletal, endothelial, and hematopoietic tissues have provided new insights into the way members of the transforming growth factor-beta (TGF-beta) superfamily regulate cellular differentiation, TGF-beta s regulate the fate of multipotential stem cells instructively (in the neural crest) by regulating the expression or function of tissue-specific transcription factors, as well as selectively On the mesenchyme) by regulating the expression of required growth factors and their receptors. During skeletal development, TGF-beta s have unique functions and act sequentially to modulate chondrocyte and osteoblast differentiation. Responsiveness to TGF-beta s changes as cells differentiate and evidence now suggests that changes in TGF-beta receptor profile may account for some of these differences. Drosophila and transgenic mouse models are now providing useful insights into mechanisms of TGF-beta action in vivo.

引用

页码：581 / 586

页数：6

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