Mitochondrial uncoupling proteins and phylogenesis -: UCP4 as the ancestral uncoupling protein

被引：83

作者：

Hanák, P ^{[1
]}

Jezek, P ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Physiol, Dept Membrane Transport Biophys, CZ-14220 Prague, Czech Republic

来源：

FEBS LETTERS | 2001年 / 495卷 / 03期

关键词：

phylogenesis of mitochondrial uncoupling; protein; specific sequence motif; Drosophila melanogaster; Caenorhabditis elegans; Dictyostelium discoideum; Arabidopsis thaliana;

D O I：

10.1016/S0014-5793(01)02338-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We searched for the previously defined uncoupling protein (UCP) signatures [Jezek, P, and Urbankova, E, (2000) IUBMB Life 49, 63-70] in genomes of Drosophila melanogaster, Caenorhabditis elegans, Dictyostelium discoideum, and Arabidopsis thaliana. We identified four UCPs in Drosophila and one in Caenorhabditis or Dictyostelium as close relatives of human UCP4 (BMCP), but distant from UCP1, UCP2, UCP3, and two plant UCPs of Arabidopsis. But the third Arabidopsis UCP is the closest UCP4 relative. This suggests that UCP3 represents the ancestral UCP from which other mammalian and plant UCPs diverged. Speculations on UCP4 participation in apoptosis are thus supported by its early phylogenetic occurrence. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：137 / 141

页数：5

共 43 条

[1] The genome sequence of Drosophila melanogaster [J].

Adams, MD ;

Celniker, SE ;

Holt, RA ;

Evans, CA ;

Gocayne, JD ;

Amanatides, PG ;

Scherer, SE ;

Li, PW ;

Hoskins, RA ;

Galle, RF ;

George, RA ;

Lewis, SE ;

Richards, S ;

Ashburner, M ;

Henderson, SN ;

Sutton, GG ;

Wortman, JR ;

Yandell, MD ;

Zhang, Q ;

Chen, LX ;

Brandon, RC ;

Rogers, YHC ;

Blazej, RG ;

Champe, M ;

Pfeiffer, BD ;

Wan, KH ;

Doyle, C ;

Baxter, EG ;

Helt, G ;

Nelson, CR ;

Miklos, GLG ;

Abril, JF ;

Agbayani, A ;

An, HJ ;

Andrews-Pfannkoch, C ;

Baldwin, D ;

Ballew, RM ;

Basu, A ;

Baxendale, J ;

Bayraktaroglu, L ;

Beasley, EM ;

Beeson, KY ;

Benos, PV ;

Berman, BP ;

Bhandari, D ;

Bolshakov, S ;

Borkova, D ;

Botchan, MR ;

Bouck, J ;

Brokstein, P .

SCIENCE, 2000, 287 (5461) :2185-2195

[2] H+ transport by uncoupling protein (UCP-1) Is dependent on a histidine pair, absent in UCP-2 and UCP-3 [J].

Bienengraeber, M ;

Echtay, KS ;

Klingenberg, M .

BIOCHEMISTRY, 1998, 37 (01) :3-8

[3] Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression [J].

Boss, O ;

Samec, S ;

PaoloniGiacobino, A ;

Rossier, C ;

Dulloo, A ;

Seydoux, J ;

Muzzin, P ;

Giacobino, JP .

FEBS LETTERS, 1997, 408 (01) :39-42

[4] A SEQUENCE RELATED TO A DNA RECOGNITION ELEMENT IS ESSENTIAL FOR THE INHIBITION BY NUCLEOTIDES OF PROTON TRANSPORT THROUGH THE MITOCHONDRIAL UNCOUPLING PROTEIN [J].

BOUILLAUD, F ;

ARECHAGA, I ;

PETIT, PX ;

RAIMBAULT, S ;

LEVIMEYRUEIS, C ;

CASTEILLA, L ;

LAURENT, M ;

RIAL, E ;

RICQUIER, D .

EMBO JOURNAL, 1994, 13 (08) :1990-1997

[5] Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean [J].

Clapham, JC ;

Arch, JRS ;

Chapman, H ;

Haynes, A ;

Lister, C ;

Moore, GBT ;

Piercy, V ;

Carter, SA ;

Lehner, I ;

Smith, SA ;

Beeley, LJ ;

Godden, RJ ;

Herrity, N ;

Skehel, M ;

Changani, KK ;

Hockings, PD ;

Reid, DG ;

Squires, SM ;

Hatcher, J ;

Trail, B ;

Latcham, J ;

Rastan, S ;

Harper, AJ ;

Cadenas, S ;

Buckingham, JA ;

Brand, MD ;

Abuin, A .

NATURE, 2000, 406 (6794) :415-418

[6] Plant uncoupling mitochondrial protein activity in mitochondria isolated from tomatoes at different stages of ripening [J].

Costa, ADT ;

Nantes, IL ;

Jezek, P ;

Leite, A ;

Arruda, P ;

Vercesi, AE .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1999, 31 (05) :527-533

[7] The DNA sequence of human chromosome 22 [J].

Dunham, I ;

Shimizu, N ;

Roe, BA ;

Chissoe, S ;

Dunham, I ;

Hunt, AR ;

Collins, JE ;

Bruskiewich, R ;

Beare, DM ;

Clamp, M ;

Smink, LJ ;

Ainscough, R ;

Almeida, JP ;

Babbage, A ;

Bagguley, C ;

Balley, J ;

Barlow, K ;

Bates, KN ;

Beasley, O ;

Bird, CP ;

Blakey, S ;

Bridgeman, AM ;

Buck, D ;

Burgess, J ;

Burrill, WD ;

Burton, J ;

Carder, C ;

Carter, NP ;

Chen, Y ;

Clark, G ;

Clegg, SM ;

Cobley, V ;

Cole, CG ;

Collier, RE ;

Connor, RE ;

Conroy, D ;

Corby, N ;

Coville, GJ ;

Cox, AV ;

Davis, J ;

Dawson, E ;

Dhami, PD ;

Dockree, C ;

Dodsworth, SJ ;

Durbin, RM ;

Ellington, A ;

Evans, KL ;

Fey, JM ;

Fleming, K ;

French, L .

NATURE, 1999, 402 (6761) :489-495

[8] Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions [J].

Echtay, KS ;

Winkler, E ;

Bienengraeber, M ;

Klingenberg, M .

BIOCHEMISTRY, 2000, 39 (12) :3311-3317

[9]

ElMoualij B, 1997, YEAST, V13, P573, DOI 10.1002/(SICI)1097-0061(199705)13:6<573::AID-YEA107>3.0.CO

[10]

2-I

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