Mitochondrial uncoupling proteins and phylogenesis -: UCP4 as the ancestral uncoupling protein

被引：83

作者：

Hanák, P ^{[1
]}

Jezek, P ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Physiol, Dept Membrane Transport Biophys, CZ-14220 Prague, Czech Republic

来源：

FEBS LETTERS | 2001年 / 495卷 / 03期

关键词：

phylogenesis of mitochondrial uncoupling; protein; specific sequence motif; Drosophila melanogaster; Caenorhabditis elegans; Dictyostelium discoideum; Arabidopsis thaliana;

D O I：

10.1016/S0014-5793(01)02338-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We searched for the previously defined uncoupling protein (UCP) signatures [Jezek, P, and Urbankova, E, (2000) IUBMB Life 49, 63-70] in genomes of Drosophila melanogaster, Caenorhabditis elegans, Dictyostelium discoideum, and Arabidopsis thaliana. We identified four UCPs in Drosophila and one in Caenorhabditis or Dictyostelium as close relatives of human UCP4 (BMCP), but distant from UCP1, UCP2, UCP3, and two plant UCPs of Arabidopsis. But the third Arabidopsis UCP is the closest UCP4 relative. This suggests that UCP3 represents the ancestral UCP from which other mammalian and plant UCPs diverged. Speculations on UCP4 participation in apoptosis are thus supported by its early phylogenetic occurrence. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：137 / 141

页数：5

共 43 条

[11] The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans [J].

Fiermonte, G ;

Palmieri, L ;

Dolce, V ;

Lasorsa, FM ;

Palmieri, F ;

Runswick, MJ ;

Walker, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) :24754-24759

[12] Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia [J].

Fleury, C ;

Neverova, M ;

Collins, S ;

Raimbault, S ;

Champigny, O ;

LeviMeyrueis, C ;

Bouillaud, F ;

Seldin, MF ;

Surwit, RS ;

Ricquier, D ;

Warden, CH .

NATURE GENETICS, 1997, 15 (03) :269-272

[13] Cloning and characterization of an uncoupling protein homolog - A potential molecular mediator of human thermogenesis [J].

Gimeno, RE ;

Dembski, M ;

Weng, X ;

Deng, NH ;

Shyjan, AW ;

Gimeno, CJ ;

Iris, F ;

Ellis, SJ ;

Woolf, EA ;

Tartaglia, LA .

DIABETES, 1997, 46 (05) :900-906

[14] The DNA sequence of human chromosome 21 [J].

Hattori, M ;

Fujiyama, A ;

Taylor, TD ;

Watanabe, H ;

Yada, T ;

Park, HS ;

Toyoda, A ;

Ishii, K ;

Totoki, Y ;

Choi, DK ;

Soeda, E ;

Ohki, M ;

Takagi, T ;

Sakaki, Y ;

Taudien, S ;

Blechschmidt, K ;

Polley, A ;

Menzel, U ;

Delabar, J ;

Kumpf, K ;

Lehmann, R ;

Patterson, D ;

Reichwald, K ;

Rump, A ;

Schillhabel, M ;

Schudy, A ;

Zimmermann, W ;

Rosenthal, A ;

Kudoh, J ;

Shibuya, K ;

Kawasaki, K ;

Asakawa, S ;

Shintani, A ;

Sasaki, T ;

Nagamine, K ;

Mitsuyama, S ;

Antonarakis, SE ;

Minoshima, S ;

Shimizu, N ;

Nordsiek, G ;

Hornischer, K ;

Brandt, P ;

Scharfe, M ;

Schön, O ;

Desario, A ;

Reichelt, J ;

Kauer, G ;

Blöcker, H ;

Ramser, J ;

Beck, A .

NATURE, 2000, 405 (6784) :311-319

[15]

Ison JC, 2000, PROTEINS, V40, P330, DOI 10.1002/(SICI)1097-0134(20000801)40:2<330::AID-PROT120>3.0.CO

[16]

2-3

[17] Isolation of two distinct cold-inducible cDNAs encoding plant uncoupling proteins from the spadix of skunk cabbage (Symplocarpus foetidus) [J].

Ito, K .

PLANT SCIENCE, 1999, 149 (02) :167-173

[18] Linoleic acid-induced activity of plant uncoupling mitochondrial protein in purified tomato fruit mitochondria during resting, phosphorylating, and progressively uncoupled respiration [J].

Jarmuszkiewicz, W ;

Almeida, AM ;

Sluse-Goffart, CM ;

Sluse, FE ;

Vercesi, AE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (52) :34882-34886

[19]

Jezek P, 2000, IUBMB LIFE, V49, P63

[20] Reconstituted plant uncoupling mitochondrial protein allows for proton translocation via fatty acid cycling mechanism [J].

Jezek, P ;

Costa, ADT ;

Vercesi, AE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (39) :24272-24278

← 1 2 3 4 5 →