Phylogenetic reconstruction of intrapatient evolution of human immunodeficiency virus type 1:: predominance of drift and purifying selection

被引：19

作者：

Kils-Hütten, L

Cheynier, R

Wain-Hobson, S

Meyerhans, A

机构：

[1] Univ Saarlandes, Abt Virol, Inst Med Mikrobiol & Hyg, Klinikum Homburg, D-66421 Homburg, Germany

[2] Inst Pasteur, Unite Retrovirol Mol, F-75724 Paris 15, France

来源：

JOURNAL OF GENERAL VIROLOGY | 2001年 / 82卷

关键词：

D O I：

10.1099/0022-1317-82-7-1621

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The intra-host evolution of 73 human immunodeficiency virus type 1 quasispecies was analysed by split decomposition analysis. Non-synonymous and synonymous nucleotide substitutions were counted along the shortest path connecting all sequences and compared with the numbers expected under the assumption of a random model of mutation. For the majority of substitutions, drift and negative selection seemed to prevail.

引用

页码：1621 / 1627

页数：7

共 32 条

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