Survival in two variants of tau-negative frontotemporal lobar degeneration: FTLD-U vs FTLD-MND

被引：67

作者：

Josephs, KA

Knopman, DS

Whitwell, JL

Boeve, BF

Parisi, JE

Petersen, RC

Dickson, DW

机构：

[1] Mayo Clin, Dept Neurol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Radiol Res, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Pathol & Neurosci, Jacksonville, FL 32224 USA

来源：

NEUROLOGY | 2005年 / 65卷 / 04期

关键词：

D O I：

10.1212/01.wnl.0000173178.67986.7f

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Pathologic diagnoses in frontotemporal lobar degeneration (FTLD) include tau-positive FTLD and tau-negative FTLD. Two variants of tau-negative FTLD are FTLD with motor neuron disease (FTLD-MND) and FTLD with motor neuron disease type inclusions but without motor neuron disease (FTLD-U). An analysis of patient outcomes in these cases reveals that FTLD-MND has significantly shorter survival than FTLD-U, suggesting that FTLD-MND is a more aggressive disease process.

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页码：645 / 647

页数：3

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