Signaling pathways activated by the growth hormone receptor

被引：264

作者：

Herrington, J ^{[1
]}

Carter-Su, C ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Physiol, Ann Arbor, MI 48109 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2001年 / 12卷 / 06期

关键词：

D O I：

10.1016/S1043-2760(01)00423-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In recent years, significant progress has been made in elucidating the signaling pathways activated by the growth hormone (GH) receptor. An initiating event is probably the activation of JAK2 (Janus kinase 2). a on receptor-associated tyrosine kinase. Identification of the proteins recruited to the GH receptor-JAK2 complex and dissection of the signaling pathways that are subsequently activated will ultimately provide a basis for understanding GH action at the molecular level.

引用

页码：252 / 257

页数：6

共 72 条

[1] Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling [J].

Adams, TE ;

Hansen, JA ;

Starr, R ;

Nicola, NA ;

Hilton, DJ ;

Billestrup, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (03) :1285-1287

[2] IDENTIFICATION OF JAK2 AS A GROWTH-HORMONE RECEPTOR-ASSOCIATED TYROSINE KINASE [J].

ARGETSINGER, LS ;

CAMPBELL, GS ;

YANG, XN ;

WITTHUHN, BA ;

SILVENNOINEN, O ;

IHLE, JN ;

CARTERSU, C .

CELL, 1993, 74 (02) :237-244

[3] Effects of growth hormone overexpression and growth hormone resistance on neuroendocrine and reproductive functions in transgenic and knock-out mice [J].

Bartke, A ;

Chandrashekar, V ;

Turyn, D ;

Steger, RW ;

Debeljuk, L ;

Winters, TA ;

Mattison, JA ;

Danilovich, NA ;

Croson, W ;

Wernsing, DR ;

Kopchick, JJ .

PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1999, 222 (02) :113-123

[4] Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation [J].

Behncken, SN ;

Billestrup, N ;

Brown, R ;

Amstrup, J ;

Conway-Campbell, B ;

Waters, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (22) :17000-17007

[5] Yin-yang 1 and glucocorticoid receptor participate in the Stat5-mediated growth hormone response of the serine protease inhibitor 2.1 gene [J].

Bergad, PL ;

Towle, HC ;

Berry, SA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (11) :8114-8120

[6] Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity [J].

Clackson, T ;

Ultsch, MH ;

Wells, JA ;

de Vos, AM .

JOURNAL OF MOLECULAR BIOLOGY, 1998, 277 (05) :1111-1128

[7] Ternary complex factors Elk-1 and Sap-1a mediate growth hormone-induced transcription of egr-1 (early growth response factor-1) in 3T3-F442A preadipocytes [J].

Clarkson, RWE ;

Shang, CA ;

Levitt, LK ;

Howard, T ;

Waters, MJ .

MOLECULAR ENDOCRINOLOGY, 1999, 13 (04) :619-631

[8]

Coculescu M, 1999, J PEDIATR ENDOCR MET, V12, P113

[9] Contribution of growth hormone and IGF-I to early diabetic nephropathy in type 1 diabetes [J].

Cummings, EA ;

Sochett, EB ;

Dekker, MG ;

Lawson, ML ;

Daneman, D .

DIABETES, 1998, 47 (08) :1341-1346

[10] STAT5 signaling in sexually dimorphic gene expression and growth patterns [J].

Davey, HW ;

Wilkins, RJ ;

Waxman, DJ .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) :959-965

← 1 2 3 4 5 6 7 8 →