Spreading depression enhances human neocortical excitability in vitro

被引：76

作者：

Berger, M. ^{[1
]}

Speckmann, E-J ^{[1
,2
]}

Pape, H. C. ^{[1
,2
]}

Gorji, A. ^{[1
]}

机构：

[1] Univ Munster, Inst Physiol 1, D-48149 Munster, Germany

[2] Univ Munster, Inst Expt Epilepsieforschung, D-48149 Munster, Germany

来源：

CEPHALALGIA | 2008年 / 28卷 / 05期

关键词：

headache; neocortex; neuronal activity; synapse;

D O I：

10.1111/j.1468-2982.2008.01556.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cortical spreading depression (CSD) plays a role in migraine with aura. However, studies of the neuronal effects of CSD in human cortex are scarce. Therefore, in the present study, the effects of CSD on the field excitatory postsynaptic potentials (fEPSP) and the induction of long-term potentiation (LTP) were investigated in human neocortical slices obtained during epilepsy surgery. CSD significantly enhanced the amplitude of fEPSP following a transient suppressive period and increased the induction of LTP in the third layer of neocortical tissues. These results indicate that CSD facilitates synaptic excitability and efficacy in human neocortical tissues, which can be assumed to contribute to hyperexcitability of neocortical tissues in patients suffering from migraine.

引用

页码：558 / 562

页数：5

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