Interleukin-7 receptor signaling network: An integrated systems perspective

被引：106

作者：

Palmer, Megan J. ^{[1
]}

Mahajan, Vinay S. ^{[1
]}

Trajman, Lily C. ^{[2
,3
]}

Irvine, Darrell J. ^{[1
,2
,3
]}

Lauffenburger, Douglas A. ^{[1
,2
,3
]}

Chen, Jianzhu ^{[2
,3
]}

机构：

[1] MIT, Dept Biol Engn, Cambridge, MA 02139 USA

[2] Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[3] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2008年 / 5卷 / 02期

关键词：

IL-7; receptor; cytokine; signaling network; systems biology; modeling;

D O I：

10.1038/cmi.2008.10

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor, the IL-7 receptor (IL-7R), activates multiple pathways that regulate lymphocyte survival, glucose uptake, proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells, including the use of shared receptor components, signaling crosstalk, shared interaction domains, feedback loops, integrated gene regulation, multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology.

引用

页码：79 / 89

页数：11

共 55 条

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