Antiangiogenic therapies for mesothelioma

被引：28

作者：

Dowell, JE

Kindler, HL

机构：

[1] Univ Texas, SW Med Ctr, Dallas, TX 75390 USA

[2] Dallas Vet Affairs Med Ctr, Div Hematol & Oncol, Dallas, TX USA

[3] Univ Chicago, Hematol Oncol Sect, Chicago, IL 60637 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2005年 / 19卷 / 06期

关键词：

D O I：

10.1016/j.hoc.2005.09.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A large body of preclinical evidence suggests that angiogenesis plays a key role in the pathogenesis of malignant mesothelioma. Several mediators of angiogenesis seem to be autocrine growth factors in mesothelioma, and in preclinical models, agents that target angiogenesis produce tumor regression. Several clinical trials are currently evaluating the efficacy of inhibitors of angiogenesis in mesothelioma. This article details the preliminary results of these trials and future directions.

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页码：1137 / +

页数：10

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