Evidence for ACE2-Utilizing Coronaviruses (CoVs) Related to Severe Acute Respiratory Syndrome CoV in Bats

被引：74

作者：

Demogines, Ann ^{[1
]}

Farzan, Michael ^{[2
]}

Sawyer, Sara L. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Mol Genet & Microbiol, Inst Cellular & Mol Biol, Austin, TX 78712 USA

[2] Harvard Univ, Sch Med, Dept Microbiol & Immunol, New England Primate Res Ctr, Southborough, MA 01772 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 11期

基金：

美国国家卫生研究院;

关键词：

CROSS-SPECIES TRANSMISSION; SARS-LIKE CORONAVIRUS; PRIMATE LENTIVIRUSES; PALM CIVETS; RECEPTOR; EVOLUTION; VIRUS; BINDING; RESERVOIRS; PROTEIN;

D O I：

10.1128/JVI.00311-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 2002, severe acute respiratory syndrome (SARS)-coronavirus (CoV) appeared as a novel human virus with high similarity to bat coronaviruses. However, while SARS-CoV uses the human angiotensin-converting enzyme 2 (ACE2) receptor for cellular entry, no coronavirus isolated from bats appears to use ACE2. Here we show that signatures of recurrent positive selection in the bat ACE2 gene map almost perfectly to known SARS-CoV interaction surfaces. Our data indicate that ACE2 utilization preceded the emergence of SARS-CoV-like viruses from bats.

引用

页码：6350 / 6353

页数：4

共 41 条

[11] Angiotensin-converting enzyme 2 (ACE2) proteins of different bat species confer variable susceptibility to SARS-CoV entry [J].

Hou, Yuxuan ;

Peng, Cheng ;

Yu, Meng ;

Li, Yan ;

Han, Zhenggang ;

Li, Fang ;

Wang, Lin-Fa ;

Shi, Zhengli .

ARCHIVES OF VIROLOGY, 2010, 155 (10) :1563-1569

[12]

Kaelber JT, PLOS PATHOG IN PRESS

[13] Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms [J].

Kan, B ;

Wang, M ;

Jing, HQ ;

Xu, HF ;

Jiang, XG ;

Yan, MY ;

Liang, WL ;

Zheng, H ;

Wan, KL ;

Liu, QY ;

Cui, BY ;

Xu, YM ;

Zhang, EM ;

Wang, HX ;

Ye, JR ;

Li, GH ;

Li, MH ;

Cui, ZG ;

Qi, XB ;

Chen, K ;

Du, L ;

Gao, K ;

Zhao, YT ;

Zou, XZ ;

Feng, YJ ;

Gao, YF ;

Hai, R ;

Yu, DZ ;

Guan, Y ;

Xu, JG .

JOURNAL OF VIROLOGY, 2005, 79 (18) :11892-11900

[14] Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: Crossing the host cell species barrier [J].

Kuo, LL ;

Godeke, GJ ;

Raamsman, MJB ;

Masters, PS ;

Rottier, PJM .

JOURNAL OF VIROLOGY, 2000, 74 (03) :1393-1406

[15] Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats [J].

Lau, SKP ;

Woo, PCY ;

Li, KSM ;

Huang, Y ;

Tsoi, HW ;

Wong, BHL ;

Wong, SSY ;

Leung, SY ;

Chan, KH ;

Yuen, KY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (39) :14040-14045

[16] Structure of SARS coronavirus spike receptor-binding domain complexed with receptor [J].

Li, F ;

Li, WH ;

Farzan, M ;

Harrison, SC .

SCIENCE, 2005, 309 (5742) :1864-1868

[17] Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections [J].

Li, Fang .

JOURNAL OF VIROLOGY, 2008, 82 (14) :6984-6991

[18] Bats are natural reservoirs of SARS-like coronaviruses [J].

Li, WD ;

Shi, ZL ;

Yu, M ;

Ren, WZ ;

Smith, C ;

Epstein, JH ;

Wang, HZ ;

Crameri, G ;

Hu, ZH ;

Zhang, HJ ;

Zhang, JH ;

McEachern, J ;

Field, H ;

Daszak, P ;

Eaton, BT ;

Zhang, SY ;

Wang, LF .

SCIENCE, 2005, 310 (5748) :676-679

[19] Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus [J].

Li, WH ;

Moore, MJ ;

Vasilieva, N ;

Sui, JH ;

Wong, SK ;

Berne, MA ;

Somasundaran, M ;

Sullivan, JL ;

Luzuriaga, K ;

Greenough, TC ;

Choe, H ;

Farzan, M .

NATURE, 2003, 426 (6965) :450-454

[20] Animal origins of the severe acute respiratory syndrome coronavirus: Insight from ACE2-S-protein interactions [J].

Li, WH ;

Wong, SK ;

Li, F ;

Kuhn, JH ;

Huang, IC ;

Choe, H ;

Farzan, M .

JOURNAL OF VIROLOGY, 2006, 80 (09) :4211-4219

← 1 2 3 4 5 →