Blood compatibility of amorphous titanium oxide films synthesized by ion beam enhanced deposition

被引:170
作者
Huang, N [1 ]
Yang, P
Cheng, X
Leong, YX
Zheng, XL
Cai, GJ
Zhen, ZH
Zhang, F
Chen, YR
Liu, XH
Xi, TF
机构
[1] SW Jiaotong Univ, Dept Mat Engn, Chengdu 610031, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Met, Ion Beam Lab, Shanghai 200050, Peoples R China
[3] Natl Inst Control Pharmaceut & Biol Prod, Ctr Med Device, Beijing 100050, Peoples R China
关键词
blood compatibility; titanium oxide film; ion beam enhanced deposition;
D O I
10.1016/S0142-9612(98)00212-9
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Titanium oxide films were synthesized on titanium, cobalt alloy and low-temperature isotropic pryolytic carbon by ion beam enhanced deposition. The non-stoichiometrical titanium oxide films were obtained. Blood compatibility of the films were evaluated by clotting time measurement, platelet adhesion investigation and hemolysis analyses. The results revealed that blood compatibility of the materials was improved by the coating of titanium oxide films. Semiconductor nature of non-stoichiometric titanium oxide films might be responsible for the improvement of blood compatibility. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:771 / 776
页数:6
相关论文
共 16 条
[1]  
Baier R E, 1969, J Biomed Mater Res, V3, P191, DOI 10.1002/jbm.820030115
[2]  
BAURSCHMIDT P, 1977, J BIOENG, V1, P261
[3]  
BOLZ A, 1990, ARTIF ORGANS, V144, P260
[4]  
Dion I., 1993, Bio-Medical Materials and Engineering, V3, P51
[5]   EX-VIVO LEUKOCYTE ADHESION AND PROTEIN ADSORPTION ON TIN [J].
DION, I ;
ROQUES, X ;
MORE, N ;
LABROUSSE, L ;
CAIX, J ;
LEFEBVRE, F ;
ROUAIS, F ;
GAUTREAU, J ;
BAQUEY, C .
BIOMATERIALS, 1993, 14 (09) :712-719
[6]  
EBERT R, 1982, WORLD C MED PHYS BIO, V3, P7
[7]  
FENG Z, 1997, CHINESE J FUNCT MAT, V3, P47
[8]  
Gutmann F., 1986, MODERN BIOELECTROCHE
[9]   NEW METHOD FOR EVALUATION OF ANTITHROMBOGENICITY OF MATERIALS [J].
IMAI, Y ;
NOSE, Y .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1972, 6 (03) :165-&
[10]  
*ISO, 74051984 ISO