The serotonin 2A -: 1438 G/A receptor polymorphism in a group of Swedish male criminals

被引：28

作者：

Berggård, C

Damberg, M

Longato-Stadler, E

Jarmila, H

Oreland, L

Garpenstrand, H

机构：

[1] Uppsala Univ, Dept Neurosci, Pharmacol Unit, SE-75124 Uppsala, Sweden

[2] Uppsala Univ, Unit Psychiat, Dept Neurosci, SE-75124 Uppsala, Sweden

来源：

NEUROSCIENCE LETTERS | 2003年 / 347卷 / 03期

关键词：

sermonin; 5-HT2A; polymorphism; association study; personality; criminality;

D O I：

10.1016/S0304-3940(03)00699-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Studies have shown that genetic components to some extent underlie behavioral disorders such as impulsive aggression and violence, and that central serotonergic mechanisms are involved in the development of such behavior. In the present study, we analyzed a polymorphism in the gene encoding the serotonin 2A receptor (5-HT2A-1438 G/A) in a group of Swedish criminals (n = 97) and in a group of healthy Swedish blood donors (n = 202). The 5-HT2A-1438 GG genotype was lower in the criminal group than in the control group (P = 0.034). In accordance with previous results, no associations were found between the 5-HT2A-1438 G/A polymorphism and personality as measured by Karolinska Scales of Personality. Neither were there any associations between the studied polymorphism and the type of crime committed. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：196 / 198

页数：3

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共 20 条

[11] Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism [J].

Nakamura, K ;

Kurasawa, M .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 420 (01) :33-43

[12] Schizophrenia and the serotonin-2A receptor promoter polymorphism [J].

Ohara, K ;

Nagai, M ;

Tani, K ;

Tsukamoto, T ;

Ohara, K .

PSYCHIATRY RESEARCH, 1999, 85 (02) :221-224

[13] SELECTIVE AGONISTS AND ANTAGONISTS FOR 5-HYDROXYTRYPTAMINE RECEPTOR SUBTYPES, AND INTERACTIONS WITH YOHIMBINE AND FG-7142 USING THE ELEVATED PLUS-MAZE TEST IN THE RAT [J].

PELLOW, S ;

JOHNSTON, AL ;

FILE, SE .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1987, 39 (11) :917-928

[14] THE GENETIC-BASIS OF COMPLEX HUMAN BEHAVIORS [J].

PLOMIN, R ;

OWEN, MJ ;

MCGUFFIN, P .

SCIENCE, 1994, 264 (5166) :1733-1739

[15] Impulsive traits and 5-HT2A receptor promoter polymorphism in alcohol dependents: Possible association but no influence of personality disorders [J].

Preuss, UW ;

Koller, G ;

Bondy, B ;

Bahlmann, M ;

Soyka, M .

NEUROPSYCHOBIOLOGY, 2001, 43 (03) :186-191

[16] PLATELET MAO ACTIVITY ASSOCIATED WITH IMPULSIVITY AND AGGRESSIVITY [J].

SCHALLING, D ;

EDMAN, G ;

ASBERG, M ;

ORELAND, L .

PERSONALITY AND INDIVIDUAL DIFFERENCES, 1988, 9 (03) :597-605

[17] The genetics of antisocial behavior. [J].

Slutske W.S. .

Current Psychiatry Reports, 2001, 3 (2) :158-162

[18] A family based association study of T102C polymorphism in 5HT2A and schizophrenia plus identification of new polymorphisms in the promoter [J].

Spurlock, G ;

Heils, A ;

Holmans, P ;

Williams, J ;

D'Souza, UM ;

Cardno, A ;

Murphy, KC ;

Jones, L ;

Buckland, PR ;

McGuffin, P ;

Lesch, KP ;

Owen, MJ .

MOLECULAR PSYCHIATRY, 1998, 3 (01) :42-49

[19] Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error? [J].

Xu, JF ;

Turner, A ;

Little, J ;

Bleecker, ER ;

Meyers, DA .

HUMAN GENETICS, 2002, 111 (06) :573-574

[20] Further lack of association between the 5-HT2A gene promoter polymorphism and susceptibility to eating disorders and a meta-analysis pertaining to anorexia nervosa [J].

Ziegler, A ;

Hebebrand, J ;

Görg, T ;

Rosenkranz, K ;

Fichter, MM ;

Herpertz-Dahlmann, B ;

Remschmidt, H ;

Hinney, A .

MOLECULAR PSYCHIATRY, 1999, 4 (05) :410-412