Polar expeditions - provisioning the centrosome for mitosis

被引：110

作者：

Blagden, SP ^{[1
]}

Glover, DM ^{[1
]}

机构：

[1] Univ Cambridge, Dept Genet, Canc Res UK Cell Cycle Genet Res Grp, Cambridge CB2 3EH, England

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 06期

关键词：

D O I：

10.1038/ncb0603-505

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1-S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional gamma-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.

引用

页码：505 / 511

页数：7

共 97 条

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