Polar expeditions - provisioning the centrosome for mitosis

被引：110

作者：

Blagden, SP ^{[1
]}

Glover, DM ^{[1
]}

机构：

[1] Univ Cambridge, Dept Genet, Canc Res UK Cell Cycle Genet Res Grp, Cambridge CB2 3EH, England

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 06期

关键词：

D O I：

10.1038/ncb0603-505

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1-S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional gamma-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.

引用

页码：505 / 511

页数：7

共 97 条

[91] The γ-tubulin complex protein Alp4 provides a link between the metaphase checkpoint and cytokinesis in fission yeast
Vardy, L
Fujita, A
Toda, T
[J]. GENES TO CELLS, 2002, 7 (04) : 365 - 373
[92] Vogel J, 2000, J CELL SCI, V113, P3871
[93] Vogel J, 2000, CURR TOP DEV BIOL, V49, P75
[94] Localization of the kinesin-like protein Xklp2 to spindle poles requires a leucine zipper, a microtubule-associated protein, and dynein
Wittmann, T
Boleti, H
Antony, C
Karsenti, E
Vernos, I
[J]. JOURNAL OF CELL BIOLOGY, 1998, 143 (03) : 673 - 685
[95] TPX2, a novel Xenopus MAP involved in spindle pole organization
Wittmann, T
Wilm, M
Karsenti, E
Vernos, I
[J]. JOURNAL OF CELL BIOLOGY, 2000, 149 (07) : 1405 - 1418
[96] Cytoplasmic dynein-mediated assembly of pericentrin and γ tubulin onto centrosomes
Young, A
Dictenberg, JB
Purohit, A
Tuft, R
Doxsey, SJ
[J]. MOLECULAR BIOLOGY OF THE CELL, 2000, 11 (06) : 2047 - +
[97] Construction of centrosomes and spindle poles by molecular motor-driven assembly of protein particles
Zimmerman, W
Doxsey, SJ
[J]. TRAFFIC, 2000, 1 (12) : 927 - 934

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