A novel artemisinin-quinine hybrid with potent antimalarial activity

被引：140

作者：

Walsh, John J. ^{[1
]}

Coughlana, David

Heneghan, Nicola

Gaynor, Caroline

Bell, Angus

机构：

[1] Univ Dublin Trinity Coll, Sch Pharm & Pharmaceut Sci, Dublin 2, Ireland

[2] Univ Dublin Trinity Coll, Moyne Inst Prevent Med, Dept Microbiol, Dublin 2, Ireland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 13期

关键词：

D O I：

10.1016/j.bmcl.2007.04.054

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Artemisinin was reduced to dihydroartemisinin and coupled to a carboxylic acid derivative of quinine via an ester linkage. This novel hybrid molecule had potent activity against the 3D7 and (drug-resistant) FcB1 strains of Plasmodium falciparum? in culture. The activity was superior to that of artemisinin alone, quinine alone, or a 1:1 mixture of artemisinin and quinine. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3599 / 3602

页数：4

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