Growing tissues in microgravity

被引：290

作者：

Unsworth, BR ^{[1
]}

Lelkes, PI

机构：

[1] Marquette Univ, Dept Biol, Milwaukee, WI 53233 USA

[2] Univ Wisconsin, Sch Med, Dept Med, Cell Biol Lab, Milwaukee, WI 53201 USA

来源：

NATURE MEDICINE | 1998年 / 4卷 / 08期

关键词：

D O I：

10.1038/nm0898-901

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possibility of creating three-dimensional differentiated tissue- like assemblies by culturing cells in microgravity, either in space or on the ground, offers research opportunities that may lead to the generation of replacement organs for transplantation, and for studying multicellular responses in toxicology, radiation biology, tumorigenesis, and embryogenesis. Here, Brian Unsworth and Peter Lelkes review these opportunities, considering the practical and theoretical challenges of the microgravity environment.

引用

页码：901 / 907

页数：7

共 77 条

[21] Chondrogenesis in a cell-polymer-bioreactor system [J].

Freed, LE ;

Hollander, AP ;

Martin, I ;

Barry, JR ;

Langer, R ;

Vunjak-Novakovic, G .

EXPERIMENTAL CELL RESEARCH, 1998, 240 (01) :58-65

[22] Tissue engineering of cartilage in space [J].

Freed, LE ;

Langer, R ;

Martin, I ;

Pellis, NR ;

VunjakNovakovic, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13885-13890

[23]

FREED LE, 1997, PRINCIPLES TISSUE EN, P151

[24]

GALVAN DL, 1995, MOL BIOL CELL, V6, P975

[25]

GALVAN DL, 1995, IN VITRO CELL DEV, V31, pA10

[26]

GOODWIN TJ, 1993, P SOC EXP BIOL MED, V202, P181

[27]

Goodwin TJ, 1997, IN VITRO CELL DEV-AN, V33, P366

[28] Demonstration of feasibility of automated osteoblastic line culture in space flight [J].

Guignandon, A ;

Genty, C ;

Vico, L ;

LafageProust, MH ;

Palle, S ;

Alexandre, C .

BONE, 1997, 20 (02) :109-116

[29]

HAMMOND TG, 1995, IN VITRO CELLD EV BI, V31, pA9

[30] TO DO TISSUE-CULTURE IN 2 OR 3 DIMENSIONS - THAT IS THE QUESTION [J].

HOFFMAN, RM .

STEM CELLS, 1993, 11 (02) :105-111

← 1 2 3 4 5 6 7 8 →