A new perspective on the mechanism of asymmetric amplification

被引：9

作者：

Asakura, K

Yamamoto, T

Inoue, S

Osanai, S

Kondepudi, DK

Yamaguchi, T

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

[2] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA

[3] Natl Inst Adv Ind Sci & Technol, AIST, Nanotechnol Res Inst, Tsukuba, Ibaraki 3058565, Japan

来源：

CHEMICAL PHYSICS LETTERS | 2005年 / 406卷 / 4-6期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/j.cplett.2005.03.009

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A mechanism of asymmetric amplification, i.e., chemical reaction in which enantiomeric excess, ee, of a product is higher than that of chiral auxiliary for catalyst, was investigated. The reaction rate and the ee of the product differed significantly when the order of reagent addition was changed. A kinetic model formulated to explain this phenomenon predicted that the ee of the product should vary during the reaction. Our experimental investigation indeed found the variation of ee predicted by this theoretical model. There has been no previous report observing such a variation in ee during asymmetric amplification and a different ee produced by changing the order of reagent addition. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：312 / 317

页数：6

共 18 条

[1] Nonlinear stereochemical effects in asymmetric reactions [J].