Localization of Sonic hedgehog secreting and receiving cells in the developing and adult rat adrenal cortex

被引：41

作者：

Guasti, Leonardo ^{[1
]}

Paul, Alex ^{[2
]}

Laufer, Ed ^{[2
]}

King, Peter ^{[1
]}

机构：

[1] Queen Mary Univ London, William Harvey Res Inst, Ctr Endocrinol, London EC1M 6BQ, England

[2] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 336卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

Sonic hedgehog; Adrenal cortex; Development; EXPRESSION; PROTEINS; ZONATION; GROWTH; GLAND; ZONE; ACTH; STEM;

D O I：

10.1016/j.mce.2010.11.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sonic hedgehog signaling was recently demonstrated to play an important role in murine adrenal cortex development. The organization of the rat adrenal differs from that of the mouse, with the zona glomerulosa and zona fasciculata separated by an undifferentiated zone in the rat, but not in the mouse. In the present study we aimed to determine the mRNA expression patterns of Sonic hedgehog and the hedgehog signaling pathway components Patched-1 and Gill in the developing and adult rat adrenal. Sonic hedgehog expression was detected at the periphery of the cortex in cells lacking CYP11B1 and CYP11B2 expression, while signal-receiving cells were localized in the overlying capsule mesenchyme. Using combined in situ hybridization and immunohistochemistry we found that the cells expressing Sonic hedgehog lie between the CYP11B2 and CYP11B1 layers, and thus Sonic hedgehog expression defines one cell population of the undifferentiated zone. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：117 / 122

页数：6

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