Wnts send axons up and down the spinal cord

被引：11

作者：

Dickson, BJ ^{[1
]}

机构：

[1] Austrian Acad Sci, Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 09期

关键词：

D O I：

10.1038/nn0905-1130

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Certain Wnts attract ascending somatosensory axons up the spinal cord toward the brain. A study in this issue shows that other Wnts guide corticospinal axons down the spinal cord, not by an attractive mechanism but by repulsion through the receptor Ryk.

引用

页码：1130 / 1132

页数：4

共 15 条

[1] Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans [J].

Colavita, A ;

Culotti, JG .

DEVELOPMENTAL BIOLOGY, 1998, 194 (01) :72-85

[2] THE UNC-5, UNC-6, AND UNC-40 GENES GUIDE CIRCUMFERENTIAL MIGRATIONS OF PIONEER AXONS AND MESODERMAL CELLS ON THE EPIDERMIS IN C-ELEGANS [J].

HEDGECOCK, EM ;

CULOTTI, JG ;

HALL, DH .

NEURON, 1990, 4 (01) :61-85

[3] RETRACTED: A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion (Publication with Expression of Concern. See vol. 186, pg. 230, 2023) (Retracted article. See vol. 186, pg. 4256, 2023) [J].

Hong, KS ;

Hinck, L ;

Nishiyama, M ;

Poo, MM ;

Tessier-Lavigne, M ;

Stein, E .

CELL, 1999, 97 (07) :927-941

[4] The ups and downs of Wnt signaling [J].

Imondi, R ;

Thomas, JB .

SCIENCE, 2003, 302 (5652) :1903-1904

[5] C-elegans LIN-18 is a Ryk ortholog in parallel to LIN-17/frizzled in Wnt and functions signaling [J].

Inoue, T ;

Oz, HS ;

Wiland, D ;

Gharib, S ;

Deshpande, R ;

Hill, RJ ;

Katz, WS ;

Sternberg, PW .

CELL, 2004, 118 (06) :795-806

[6] Short- and long-range repulsion by the Drosophila Unc5 netrin receptor [J].

Keleman, K ;

Dickson, BJ .

NEURON, 2001, 32 (04) :605-617

[7] Ryk-mediated Wnt repulsion regulates posterior-directed growth of corticospinal tract [J].

Liu, YB ;

Shi, J ;

Lu, CC ;

Wang, ZB ;

Lyuksyutova, AI ;

Song, XJ ;

Zou, YM .

NATURE NEUROSCIENCE, 2005, 8 (09) :1151-1159

[8] Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth [J].

Lu, WG ;

Yamamoto, V ;

Ortega, B ;

Baltimore, D .

CELL, 2004, 119 (01) :97-108

[9] Anterior-posterior guidance of commissural Axons by Wnt-frizzled signaling [J].

Lyuksyutova, AI ;

Lu, CC ;

Milanesio, N ;

King, LA ;

Guo, NN ;

Wang, YS ;

Nathans, J ;

Tessier-Lavigne, M ;

Zou, YM .

SCIENCE, 2003, 302 (5652) :1984-1988

[10] Change in chemoattractant responsiveness of developing axons at an intermediate target [J].

Shirasaki, R ;

Katsumata, R ;

Murakami, F .

SCIENCE, 1998, 279 (5347) :105-107

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