Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia

被引：625

作者：

Kanda, Mitsuro

Matthaei, Hanno

Wu, Jian ^{[2
]}

Hong, Seung-Mo

Yu, Jun

Borges, Michael

Hruban, Ralph H. ^{[2
]}

Maitra, Anirban ^{[2
]}

Kinzler, Kenneth ^{[2
]}

Vogelstein, Bert ^{[2
]}

Goggins, Michael ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Sol Goldman Pancreat Canc Res Ctr, Sch Med, Dept Pathol,Johns Hopkins Med Inst, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sol Goldman Pancreat Canc Res Ctr, Sch Med, Dept Oncol, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Sol Goldman Pancreat Canc Res Ctr, Sch Med, Dept Med, Baltimore, MD 21231 USA

来源：

GASTROENTEROLOGY | 2012年 / 142卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Pancreatic Cancer; Tumorigenesis; Transformation; Neoplasm; SENESCENCE; CANCER; CELLS; DNA;

D O I：

10.1053/j.gastro.2011.12.042

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

More information is needed about genetic factors that initiate development of pancreatic intraepithelial neoplasms-the most common precursors of pancreatic ductal adenocarcinoma. We show that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF. These findings could improve our understanding of the development and progression of these premalignant lesions.

引用

页码：730 / U129

页数：13

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