Senescence-messaging secretome: SMS-ing cellular stress

被引：690

作者：

Kuilman, Thomas ^{[1
]}

Peeper, Daniel S. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

NATURE REVIEWS CANCER | 2009年 / 9卷 / 02期

关键词：

FACTOR-BINDING PROTEIN-3; GROWTH-FACTOR-BETA; RECEPTOR-RELATED-PROTEIN; ACTIVATOR INHIBITOR TYPE-1; ONCOGENE-INDUCED SENESCENCE; BREAST-CANCER CELLS; INSULIN SIGNAL-TRANSDUCTION; MOLECULAR-WEIGHT COMPLEX; SMOOTH-MUSCLE-CELLS; II IGF-II;

D O I：

10.1038/nrc2560

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Oncogene-induced cellular senescence constitutes a strong anti-proliferative response, which can be set in motion following either oncogene activation or loss of tumour suppressor signalling. It serves to limit the expansion of early neoplastic cells and as such is a potent cancer-protective response to oncogenic events. Recently emerging evidence points to a crucial role in oncogene-induced cellular senescence for the 'senescence-messaging secretome' or SMS, setting the stage for cross-talk between senescent cells and their environment. How are such signals integrated into a coordinated response and what are the implications of this unexpected finding?

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页码：81 / 94

页数：14

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