A plant Shaker-like K+ channel switches between two distinct gating modes resulting in either inward-rectifying or 'leak' current

被引：67

作者：

Dreyer, I ^{[1
]}

Michard, E ^{[1
]}

Lacombe, B ^{[1
]}

Thibaud, JB ^{[1
]}

机构：

[1] Agro M CNRS INRA UM2, UMR 5004, Lab Biochim & Physiol Mol Plantes, F-34060 Montpellier 1, France

来源：

FEBS LETTERS | 2001年 / 505卷 / 02期

关键词：

potassium channel; voltage-gating; post-translational modification; patch-clamp;

D O I：

10.1016/S0014-5793(01)02832-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among the Shaker-like plant potassium channels, AKT2 is remarkable because it mediates both instantaneous 'leak-like' and time-dependent hyperpolarisation-activated currents. This unique gating behaviour has been analysed in Xenopus oocytes and in COS and Chinese hamster ovary cells. Whole-cell and single-channel data show that (i) AKT2 channels display two distinct gating modes, (ii) the gating of a given AKT2 channel can change from one mode to the other and (iii) this conversion is under the control of post-translational factor(s). This behaviour is strongly reminiscent of that of the KCNK2 channel, recently reported to be controlled by its phosphorylation state. (C) 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：233 / 239

页数：7

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