Pharmacokinetics of total and unbound ertapenem in healthy elderly subjects

被引：39

作者：

Musson, DG ^{[1
]}

Majumdar, A ^{[1
]}

Holland, S ^{[1
]}

Birk, K ^{[1
]}

Xi, L ^{[1
]}

Mistry, G ^{[1
]}

Sciberras, D ^{[1
]}

Muckow, J ^{[1
]}

Deutsch, P ^{[1
]}

Rogers, JD ^{[1
]}

机构：

[1] Merck Res Labs, W Point, PA 19486 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 02期

关键词：

D O I：

10.1128/AAC.48.2.521-524.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ertapenem is a new once-a-day parenteral carbapenem antimicrobial agent. The pharmacokinetics of unbound and total concentrations of ertapenem in plasma were investigated in elderly subjects and compared with historical data from young adults. In a single- and multiple-dose study, healthy elderly males and females (n = 14) 65 years old or older were given a 1-g intravenous (i.v.) dose once daily for 7 days. Plasma and urine samples collected for 24 h on days 1 and 7 following administration of the I-g doses were analyzed by reversed-phase high-performance liquid chromatography. Areas under the concentration-time curve from 0 h to infinity (AUC(0-infinity)) for elderly females and males were similar following administration of I-g single i.v. doses, and thus, the genders were pooled in subsequent analyses. Concentrations in plasma and the half-life of ertapenem were generally higher and longer, respectively, in elderly subjects than in young adults. The mean AUC(0-infinity) of total ertapenem in the elderly was 39% higher than that in young subjects following administration of a 1-g dose. The differences were slightly greater for the mean AUC(0-infinity) of unbound ertapenem (71%). The unbound fraction of ertapenem in elderly subjects (similar to5 to 11%) was generally greater than that in young adults (similar to5 to 8%). As in young adults, ertapenem did not accumulate upon multiple dosing in the elderly. The pharmacokinetics of ertapenem in elderly subjects, while slightly different from those in young adults, do not require a dosage adjustment for elderly patients.

引用

页码：521 / 524

页数：4

共 7 条

[1] CLINICAL PHARMACOKINETIC CONSIDERATIONS IN THE ELDERLY - AN UPDATE [J].