Plagiarized bacterial genes in the human book of life

被引：11

作者：

Ponting, CP ^{[1
]}

机构：

[1] Univ Oxford, Funct Genet Unit, Dept Human Anat & Genet, MRC, Oxford OX1 3QX, England

来源：

TRENDS IN GENETICS | 2001年 / 17卷 / 05期

关键词：

D O I：

10.1016/S0168-9525(01)02282-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The initial analysis of the human genome draft sequence reveals that our 'book of life' is multi-authored. A small but significant proportion of our genes owes their heritage not to antecedent eukaryotes but instead to bacteria. The publicly funded Human Genome Project study indicates that about 0.5% of all human genes were copied into the genome from bacterial sources. Detailed sequence analyses point to these 'horizontal gene transfer' events having occurred relatively recently. So how did the hu man 'book of life' evolve to be a chimaera, part animal and part bacterium? And what was the probable evolutionary impact of such gene plagiarism?

引用

页码：235 / 237

页数：3

共 11 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2] The genome sequence of Rickettsia prowazekii and the origin of mitochondria [J].

Andersson, SGE ;

Zomorodipour, A ;

Andersson, JO ;

Sicheritz-Pontén, T ;

Alsmark, UCM ;

Podowski, RM ;

Näslund, AK ;

Eriksson, AS ;

Winkler, HH ;

Kurland, CG .

NATURE, 1998, 396 (6707) :133-140

[3] Horizontal gene transfer and the origin of species: lessons from bacteria [J].

de la Cruz, F ;

Davies, J .

TRENDS IN MICROBIOLOGY, 2000, 8 (03) :128-133

[4]

Doolittle WE, 1998, TRENDS GENET, V14, P307

[5] Evolution of organellar genomes [J].

Gray, MW .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (06) :678-687

[6] IDENTIFICATION OF ANGIOGENIC ACTIVITY AND THE CLONING AND EXPRESSION OF PLATELET-DERIVED ENDOTHELIAL-CELL GROWTH-FACTOR [J].

ISHIKAWA, F ;

MIYAZONO, K ;

HELLMAN, U ;

DREXLER, H ;

WERNSTEDT, C ;

HAGIWARA, K ;

USUKI, K ;

TAKAKU, F ;

RISAU, W ;

HELDIN, CH .

NATURE, 1989, 338 (6216) :557-562

[7] Initial sequencing and analysis of the human genome [J].

Lander, ES ;

Int Human Genome Sequencing Consortium ;

Linton, LM ;

Birren, B ;

Nusbaum, C ;

Zody, MC ;

Baldwin, J ;

Devon, K ;

Dewar, K ;

Doyle, M ;

FitzHugh, W ;

Funke, R ;

Gage, D ;

Harris, K ;

Heaford, A ;

Howland, J ;

Kann, L ;

Lehoczky, J ;

LeVine, R ;

McEwan, P ;

McKernan, K ;

Meldrim, J ;

Mesirov, JP ;

Miranda, C ;

Morris, W ;

Naylor, J ;

Raymond, C ;

Rosetti, M ;

Santos, R ;

Sheridan, A ;

Sougnez, C ;

Stange-Thomann, N ;

Stojanovic, N ;

Subramanian, A ;

Wyman, D ;

Rogers, J ;

Sulston, J ;

Ainscough, R ;

Beck, S ;

Bentley, D ;

Burton, J ;

Clee, C ;

Carter, N ;

Coulson, A ;

Deadman, R ;

Deloukas, P ;

Dunham, A ;

Dunham, I ;

Durbin, R ;

French, L .

NATURE, 2001, 409 (6822) :860-921

[8] Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest [J].

Lefebvre, L ;

Viville, S ;

Barton, SC ;

Ishino, F ;

Keverne, EB ;

Surani, MA .

NATURE GENETICS, 1998, 20 (02) :163-169

[9] Lateral gene transfer and the nature of bacterial innovation [J].

Ochman, H ;

Lawrence, JG ;

Groisman, EA .

NATURE, 2000, 405 (6784) :299-304

[10] Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer [J].

Ponting, CP ;

Aravind, L ;

Schultz, J ;

Bork, P ;

Koonin, EV .

JOURNAL OF MOLECULAR BIOLOGY, 1999, 289 (04) :729-745

← 1 2 →