Th17 Cells Mediate Clade-Specific, Serotype-Independent Mucosal Immunity

被引：150

作者：

Chen, Kong ^{[1
,2
]}

McAleer, Jeremy P. ^{[1
,2
]}

Lin, Yuan ^{[1
]}

Paterson, David L. ^{[3
]}

Zheng, Mingquan ^{[1
,2
]}

Alcorn, John F. ^{[2
]}

Weaver, Casey T. ^{[4
]}

Kolls, Jay K. ^{[1
,2
]}

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, Dept Genet, New Orleans, LA 70112 USA

[2] Childrens Hosp Pittsburgh, Pittsburgh, PA 15224 USA

[3] Univ Queensland, Mater Adults Hosp, Brisbane, Qld 4101, Australia

[4] Univ Alabama Birmingham, Birmingham, AL 35294 USA

来源：

IMMUNITY | 2011年 / 35卷 / 06期

基金：

美国国家卫生研究院;

关键词：

MYCOBACTERIUM-TUBERCULOSIS; HOST-DEFENSE; IL-17;

D O I：

10.1016/j.immuni.2011.10.018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The interleukin-17 (IL-17) family of cytokines phylogenetically predates the evolution of T cells in jawed vertebrates, suggesting that the ontogeny of the Th17 cell lineage must have arisen to confer an evolutionary advantage to the host over innate sources of IL-17. Utilizing a model of nnucosal immunization with the encapsulated bacteria Klebsiella pneumoniae, we found that B cells, which largely recognized polysaccharide capsular antigens, afforded protection to only the vaccine strain. In contrast, memory Th17 cells proliferated in response to conserved outer membrane proteins and conferred protection against several serotypes of K. pneumoniae, including the recently described multidrug resistant New Dehli metallolactamase strain. Notably, this heterologous, clade-specific protection was antibody independent, demonstrating the Th17 cell lineage confers a host advantage by providing heterologous mucosal immunity independent of serotype-specific antibody.

引用

页码：997 / 1009

页数：13

共 27 条

[1] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[2] Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling [J].

Chung, Yeonseok ;

Chang, Seon Hee ;

Martinez, Gustavo J. ;

Yang, Xuexian O. ;

Nurieva, Roza ;

Kang, Hong Soon ;

Ma, Li ;

Watowich, Stephanie S. ;

Jetten, Anton M. ;

Tian, Qiang ;

Dong, Chen .

IMMUNITY, 2009, 30 (04) :576-587

[3] Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved [J].

Comas, Inaki ;

Chakravartti, Jaidip ;

Small, Peter M. ;

Galagan, James ;

Niemann, Stefan ;

Kremer, Kristin ;

Ernst, Joel D. ;

Gagneux, Sebastien .

NATURE GENETICS, 2010, 42 (06) :498-U41

[4] TH 17 cells in development:: an updated view of their molecular identity and genetic programming [J].

Dong, Chen .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (05) :337-348

[5] TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection [J].

Fei, Mingjian ;

Bhatia, Shikha ;

Oriss, Timothy B. ;

Yarlagadda, Manohar ;

Khare, Anupriya ;

Akira, Shizuo ;

Saijo, Shinobu ;

Iwakura, Yoichiro ;

Junecko, Beth A. Fallert ;

Reinhart, Todd A. ;

Foreman, Oded ;

Ray, Prabir ;

Kolls, Jay ;

Ray, Anuradha .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (13) :5360-5365

[6] Dual nature of the adaptive immune system in lampreys [J].

Guo, Peng ;

Hirano, Masayuki ;

Herrin, Brantley R. ;

Li, Jianxu ;

Yu, Cuiling ;

Sadlonova, Andrea ;

Cooper, Max D. .

NATURE, 2009, 459 (7248) :796-U1

[7] Multiresistant Gram-negative infections: a global perspective [J].

Ho, Jennifer ;

Tambyah, Paul A. ;

Paterson, David L. .

CURRENT OPINION IN INFECTIOUS DISEASES, 2010, 23 (06) :546-553

[8] Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosa [J].

Khader, S. A. ;

Gaffen, S. L. ;

Kolls, J. K. .

MUCOSAL IMMUNOLOGY, 2009, 2 (05) :403-411

[9] IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge [J].

Khader, Shabaana A. ;

Bell, Guy K. ;

Pearl, John E. ;

Fountain, Jeffrey J. ;

Rangel-Moreno, Javier ;

Cilley, Garth E. ;

Shen, Fang ;

Eaton, Sheri M. ;

Gaffen, Sarah L. ;

Swain, Susan L. ;

Locksley, Richard M. ;

Haynes, Laura ;

Randall, Troy D. ;

Cooper, Andrea M. .

NATURE IMMUNOLOGY, 2007, 8 (04) :369-377

[10]

Kohler Jonathan E, 2007, Surg Infect (Larchmt), V8, P227, DOI 10.1089/sur.2006.007

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