Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham Heart Study

被引：172

作者：

Fox, Caroline S. ^{[1
,2
,3
,4
]}

Pencina, Michaei J. ^{[1
,5
]}

Wilson, Peter W. F. ^{[6
]}

Paynter, Nina P. ^{[1
,5
]}

Vasan, Ramachandran S. ^{[1
,7
]}

D'agostino, Ralph B. ^{[1
,5
]}

机构：

[1] NHLBI, Framingham Heart Study, Framingham, MA USA

[2] NHLBI, Bethesda, MD 20892 USA

[3] Brigham & Womens Hosp, Div Endocrinol Metab & Hypertens, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Boston, MA USA

[5] Boston Univ, Dept Math, Boston, MA 02215 USA

[6] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA

[7] Boston Univ, Sch Med, Boston, MA 02118 USA

来源：

DIABETES CARE | 2008年 / 31卷 / 08期

关键词：

D O I：

10.2337/dc08-0025

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - We assessed the lifetime risk of cardiovascular disease (CVD) among individuals with and without obesity and diabetes. RESEARCH DESIGN AND METHODS - Participants were drawn from the original and offspring cohorts of the Framingham Heart Study. Lifetime (30-year) risk of CVD was assessed using a modified Kaplan-Meier approach adjusting for the competing risk of death, beginning from age 50 years. RESULTS - Over 30 years, the lifetime risk of CVD among women With diabetes was 54.8% among normal-weight women and 78.8% among obese women. Among normal-weight men with diabetes, the lifetime risk of CVD was 78.6%, whereas it was 86.9% among obese men. CONCLUSIONS - The lifetime risk of CVD among individuals with diabetes is high, and this relationship is further accentuated with increasing adiposity.

引用

页码：1582 / 1584

页数：3