A Cellular View of Nf2 in Liver Homeostasis and Tumorigenesis

被引:4
作者
Breuhahn, Kai [1 ]
Schirmacher, Peter [1 ]
机构
[1] Univ Heidelberg Hosp, Inst Pathol, D-69120 Heidelberg, Germany
关键词
HEPATOCELLULAR-CARCINOMA; SIZE; PROLIFERATION; NF2/MERLIN; MAMMALS; PATHWAY; GROWTH;
D O I
10.1016/j.devcel.2010.08.015
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
引用
收藏
页码:363 / 364
页数:2
相关论文
共 10 条
[1]
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver [J].
Benhamouche, Samira ;
Curto, Marcello ;
Saotome, Ichiko ;
Gladden, Andrew B. ;
Liu, Ching-Hui ;
Giovannini, Marco ;
McClatchey, Andrea I. .
GENES & DEVELOPMENT, 2010, 24 (16) :1718-1730
[2]
Dysregulation of growth factor signaling in human hepatocellular carcinoma [J].
Breuhahn, K. ;
Longerich, T. ;
Schirmacher, P. .
ONCOGENE, 2006, 25 (27) :3787-3800
[3]
YAP1 increases organ size and expands undifferentiated progenitor cells [J].
Camargo, Fernando D. ;
Gokhale, Sumita ;
Johnnidis, Jonathan B. ;
Fu, Dongdong ;
Bell, George W. ;
Jaenisch, Rudolf ;
Brummelkamp, Thijn R. .
CURRENT BIOLOGY, 2007, 17 (23) :2054-2060
[4]
Elucidation of a universal size-control mechanism in Drosophila and mammals [J].
Dong, Jixin ;
Feldmann, Georg ;
Huang, Jianbin ;
Wu, Shian ;
Zhang, Nailing ;
Comerford, Sarah A. ;
Gayyed, Mariana F. ;
Anders, Robert A. ;
Maitra, Anirban ;
Pan, Duojia .
CELL, 2007, 130 (06) :1120-1133
[5]
The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis [J].
Hamaratoglu, F ;
Willecke, M ;
Kango-Singh, M ;
Nolo, R ;
Hyun, E ;
Tao, CY ;
Jafar-Nejad, H ;
Halder, G .
NATURE CELL BIOLOGY, 2006, 8 (01) :27-U9
[6]
KANAI Y, 1995, JPN J CLIN ONCOL, V25, P1
[7]
The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis [J].
Lee, Kwang-Pyo ;
Lee, Joo-Hyeon ;
Kim, Tae-Shin ;
Kim, Tack-Hoon ;
Park, Hee-Dong ;
Byun, Jin-Seok ;
Kim, Min-Chul ;
Jeong, Won-Il ;
Calvisi, Diego F. ;
Kim, Jin-Man ;
Lim, Dae-Sik .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (18) :8248-8253
[8]
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver [J].
Lu, Li ;
Li, Ying ;
Kim, Soo Mi ;
Bossuyt, Wouter ;
Liu, Pu ;
Qiu, Qiong ;
Wang, Yingdi ;
Halder, Georg ;
Finegold, Milton J. ;
Lee, Ju-Seog ;
Johnson, Randy L. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (04) :1437-1442
[9]
The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals [J].
Zhang, Nailing ;
Bai, Haibo ;
David, Karen K. ;
Dong, Jixin ;
Zheng, Yonggang ;
Cai, Jing ;
Giovannini, Marco ;
Liu, Pentao ;
Anders, Robert A. ;
Pan, Duojia .
DEVELOPMENTAL CELL, 2010, 19 (01) :27-38
[10]
Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene [J].
Zhou, Dawang ;
Conrad, Claudius ;
Xia, Fan ;
Park, Ji-Sun ;
Payer, Bernhard ;
Yin, Yi ;
Lauwers, Gregory Y. ;
Thasler, Wolfgang ;
Lee, Jeannie T. ;
Avruch, Joseph ;
Bardeesy, Nabeel .
CANCER CELL, 2009, 16 (05) :425-438