Bioreducible polymers for gene delivery

被引：101

作者：

Kim, Tae-il ^{[2
]}

Kim, Sung Wan ^{[1
,3
]}

机构：

[1] Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Ctr Controlled Chem Delivery, Salt Lake City, UT 84112 USA

[2] Seoul Natl Univ, Coll Agr & Life Sci, Dept Biosyst & Biomat Sci & Engn, Seoul, South Korea

[3] Hanyang Univ, Coll Engn, Dept Bioengn, Seoul 133791, South Korea

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2011年 / 71卷 / 03期

关键词：

Bioreducible polymers; Gene delivery; Reducing environment; PEI; Polypeptide; Polyion complex micelle; Poly(amido amine); POLY(AMIDO AMINE)S; IN-VIVO; DISULFIDE LINKAGES; BLOCK-COPOLYMERS; SIRNA DELIVERY; TAT PEPTIDE; VEGF SIRNA; DNA; MICELLES; CARRIER;

D O I：

10.1016/j.reactfunctpolym.2010.11.016

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Bioreducible polymers, which possess mainly disulfide linkages in the polymer structures, have appeared as ideal gene delivery carriers due to the high stability in extracellular physiological condition and bioreduction-triggered release of genetic materials, as well as decreased cytotoxicity because intracellular cytosol is a reducing environment containing high level of reducing molecules such as glutathione. This review will describe the initiation and recent advances in the development of bioreducible polymers for gene delivery, which includes reducibly cross-linked PEIs, polypeptides, polyion complex micelles, and poly(amido amine)s. There have been extensive researches performed to exhibit great gene delivery efficacy but still several important issues about pharmacokinetics or safety should be answered thoroughly for further rational design of bioreducible polymers having potentials in human gene delivery systems. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：344 / 349

页数：6

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