Role of Functional Imaging in the Management of Lymphoma

被引:210
作者
Cheson, Bruce D. [1 ]
机构
[1] Georgetown Univ Hosp, Div Hematol Oncol, Washington, DC 20007 USA
关键词
POSITRON-EMISSION-TOMOGRAPHY; B-CELL LYMPHOMA; NON-HODGKINS-LYMPHOMA; HIGH-DOSE CHEMOTHERAPY; FDG-PET SCAN; COLONY-STIMULATING FACTOR; SUV-BASED ASSESSMENT; FOLLOW-UP; F-18; FLUORODEOXYGLUCOSE; PROGNOSTIC VALUE;
D O I
10.1200/JCO.2010.32.5225
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
18-F-fluorodeoxyglucose (FDG) -positron emission tomography (PET), and more recently PET/computed tomography (CT), is the most sensitive and specific imaging technique currently available for patients with lymphoma. Nevertheless, despite being increasingly used in pretreatment assessment, midtreatment evaluation of response, post-treatment restaging, and surveillance during follow-up of patients with lymphoma, its impact on clinical outcome in most clinical situations remains to be confirmed. PET/CT provides its greatest clinical benefit in the posttreatment evaluation of Hodgkin's lymphoma and diffuse large B-cell lymphoma; however, the role of metabolic imaging in other indications and in other histologies remains to be demonstrated. Ongoing risk-adapted studies will hopefully provide evidence for clinical improvement on the basis of altering treatment as a result of interim PET results. Efforts are ongoing to better standardize the conduct and interpretation of FDG-PET scans. FDG-PET has the potential to improve lymphoma patient management; however, its usefulness will likely vary by histology, stage, therapy, and clinical setting. J Clin Oncol 29: 1844-1854. (C) 2011 by American Society of Clinical Oncology
引用
收藏
页码:1844 / 1854
页数:11
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