RNA editing by base deamination: more enzymes, more targets, more mysteries

被引：189

作者：

Gerber, AP ^{[1
]}

Keller, W ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, Dept Cell Biol, CH-4055 Basel, Switzerland

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 06期

关键词：

D O I：

10.1016/S0968-0004(01)01827-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The posttranscriptional modification of messenger RNA precursors (pre-mRNAs) by base deamination can profoundly alter the physiological function of the encoded proteins. The recent identification of tRNA-specific adenosine deaminases (ADATs) has led to the suggestion that these enzymes, as well as the cytidine and adenosine deaminases acting on pre-mRNAs (CDARs and ADARs), belong to a superfamily of RNA-dependent deaminases. This superfamily might have evolved from an ancient cytidine deaminase, This article reviews the reactions catalysed by these enzymes and discusses their evolutionary relationships.

引用

页码：376 / 384

页数：9

共 58 条

[1] C to U editing of the anticodon of imported mitochondrial tRNATrp allows decoding of the UGA stop codon in Leishmania tarentolae [J].

Alfonzo, JD ;

Blanc, V ;

Estévez, AM ;

Rubio, MAT ;

Simpson, L .

EMBO JOURNAL, 1999, 18 (24) :7056-7062

[2] A phylogenetic analysis reveals an unusual sequence conservation within introns involved in RNA editing [J].

Aruscavage, PJ ;

Bass, BL .

RNA, 2000, 6 (02) :257-269

[3] Mechanism, specificity and general properties of the yeast enzyme catalysing the formation of inosine 34 in the anticodon of transfer RNA [J].

Auxilien, S ;

Crain, PF ;

Trewyn, RW ;

Grosjean, H .

JOURNAL OF MOLECULAR BIOLOGY, 1996, 262 (04) :437-458

[4]

Bass BL, 1997, RNA, V3, P947

[5] (O)over-cap | identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing [J].

Blanc, V ;

Navaratnam, N ;

Henderson, JO ;

Anant, S ;

Kennedy, S ;

Jarmuz, A ;

Scott, J ;

Davidson, NO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (13) :10272-10283

[6] Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing [J].

Bourara, K ;

Litvak, S ;

Araya, A .

SCIENCE, 2000, 289 (5484) :1564-1566

[7] EARLY-ONSET EPILEPSY AND POSTNATAL LETHALITY ASSOCIATED WITH AN EDITING-DEFICIENT GLUR-B ALLELE IN MICE [J].

BRUSA, R ;

ZIMMERMANN, F ;

KOH, DS ;

FELDMEYER, D ;

GASS, P ;

SEEBURG, PH ;

SPRENGEL, R .

SCIENCE, 1995, 270 (5242) :1677-1680

[8] Regulation of serotonin-2C receptor G-protein coupling by RNA editing [J].

Burns, CM ;

Chu, H ;

Rueter, SM ;

Hutchinson, LK ;

Canton, H ;

SandersBush, E ;

Emeson, RB .

NATURE, 1997, 387 (6630) :303-308

[9] A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains [J].

Chen, CX ;

Cho, DSC ;

Wang, QD ;

Lai, F ;

Carter, KC ;

Nishikura, K .

RNA, 2000, 6 (05) :755-767

[10] RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA [J].

Chester, A ;

Scott, J ;

Anant, S ;

Navaratnam, N .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2000, 1494 (1-2) :1-13

← 1 2 3 4 5 6 →