Lipid and mechano-gated 2P domain K+ channels

被引：240

作者：

Patel, AJ ^{[1
]}

Lazdunski, M ^{[1
]}

Honoré, E ^{[1
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, UMR 6097, F-06560 Valbonne, France

来源：

CURRENT OPINION IN CELL BIOLOGY | 2001年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0955-0674(00)00231-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The two pore domain K+ channels TREK and TRAAK are opened by membrane stretch. The activating mechanical force comes from the bilayer membrane and is independent of the cytoskeleton. Emerging work shows that mechano-gated TREK and TRAAK are opened by,various lipids,including long chain polyunsaturated anionic fatty acids and neutral cone-shaped: lysophospholipids. TREK-1 shares the properties of the Aplysia neuronal S channel, a presynaptic background K+ channel involved in behavioral sensitization, a simple form of learning.

引用

页码：422 / 427

页数：6

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