Network News: Innovations in 21st Century Systems Biology

被引：32

作者：

Arkin, Adam P. ^{[1
,4
]}

Schaffer, David V. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[4] EO Lawrence Berkeley Natl Lab, Phys Biosci Div, Berkeley, CA 94720 USA

来源：

CELL | 2011年 / 144卷 / 06期

基金：

美国国家卫生研究院;

关键词：

STOCHASTIC GENE-EXPRESSION; MOTIFS; GENOME; CELLS; STRATEGIES; DIVERSITY; PATHWAY; MODULE; MODEL; YEAST;

D O I：

10.1016/j.cell.2011.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A decade ago, seminal perspectives and papers set a strong vision for the field of systems biology, and a number of these themes have flourished. Here, we describe key technologies and insights that have elucidated the evolution, architecture, and function of cellular networks, ultimately leading to the first predictive genome-scale regulatory and metabolic models of organisms. Can systems approaches bridge the gap between correlative analysis and mechanistic insights?

引用

页码：844 / 849

页数：6

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