Pharmacokinetic interaction between voriconazole and ciclosporin A following allogeneic bone marrow transplantation

被引：38

作者：

Groll, AH ^{[1
]}

Kolve, H ^{[1
]}

Ehlert, K ^{[1
]}

Paulussen, M ^{[1
]}

Vormoor, J ^{[1
]}

机构：

[1] Univ Childrens Hosp, Dept Pediat Hematol Oncol, Ctr Bone Marrow Transplantat, Infect Dis Res Program, D-48129 Munster, Germany

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2004年 / 53卷 / 01期

关键词：

antifungals; CYP450; isoenzymes; graft-versus-host disease;

D O I：

10.1093/jac/dkh022

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Voriconazole is a novel antifungal triazole that undergoes extensive oxidative metabolization involving several CYP450 isoenzymes. We report the case of a 14-year-old patient who received voriconazole concomitant with ciclosporin A as secondary antifungal prophylaxis after bone marrow transplantation. Temporary discontinuation of voriconazole due to worsening liver function tests (LFTs) resulted in a sudden drop of ciclosporin A trough levels in blood. Ciclosporin A trough levels returned to baseline following normalization of LFTs and re-institution of voriconazole. This report emphasizes the need for careful monitoring and dose adjustments of ciclosporin A in patients receiving concomitant voriconazole, and in whom voriconazole is discontinued in order to prevent subtherapeutic ciclosporin A levels with the potential consequence of graft-versus-host disease.

引用

页码：113 / 114

页数：2

共 5 条

[1] Clinical pharmacology of antifungal compounds [J].