Endosomal sorting and signalling: an emerging role for sorting nexins

被引：320

作者：

Cullen, Peter J. ^{[1
]}

机构：

[1] Univ Bristol, Sch Med Sci, Univ Walk, Dept Biochem,Henry Wellcome Integrated Signalling, Bristol BS8 1TD, Avon, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrm2427

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The endocytic network comprises a series of interconnected tubulo-vesicular membranous compartments that together regulate various sorting and signalling events. Although it is clear that defects in endocytic function underlie a variety of human diseases, our understanding of the molecular entities that regulate these sorting and signalling events remains limited. Here we discuss the sorting nexins family of proteins and propose that they have a fundamental role in orchestrating the formation of protein complexes that are involved in endosomal sorting and signalling.

引用

收藏

页码：574 / 582

页数：10

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