Antibody response to chlamydial heat shock protein 60 is strongly associated with acute coronary syndromes

被引:59
作者
Biasucci, LM
Liuzzo, G
Ciervo, A
Petrucca, A
Piro, M
Angiolillo, DJ
Crea, F
Cassone, A
Maseri, A
机构
[1] Catholic Univ, Inst Cardiol, I-00168 Rome, Italy
[2] Ist Super Sanita, Dept Bacteriol & Med Mycol, I-00161 Rome, Italy
[3] Univ Vita & Salute, Cardiothorac & Vasc Dept, Milan, Italy
关键词
angina; infarction; infection; inflammation;
D O I
10.1161/01.CIR.0000078632.76653.6C
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-Heat shock proteins (HSPs) are a family of proteins with immunogenic and proinflammatory properties. Human and Chlamydia pneumoniae (Cp) HSP60 were found in patients with stable coronary disease. Methods and Results - We measured the levels of anti - Cp- HSP60 and anti-Cp immunoglobulin G (IgG) in 179 patients with unstable angina, 40 with acute myocardial infarction, and 40 with stable angina ( SA), as well as 100 control subjects. Forty-one patients with acute coronary syndromes (ACS) were also studied at follow-up. We also measured plasma levels of high-sensitivity C-reactive protein (hs-CRP) and troponin T (TnT). Seropositivity to Cp- HSP60 was found in 99% of ACS patients but in only 20% of SA patients and none of the control subjects. Seropositivity to Cp was detected in 67% of ACS patients, 60% of SA patients, and 30% of the control subjects. No differences in Cp- HSP60 IgG and in Cp IgG were observed between patients with myocardial infarction and patients with unstable angina. No correlation was found between Cp- HSP60 IgG, TnT, and hs-CRP or between IgG against Cp and hs-CRP. In ACS patients at follow-up, Cp-HSP60 IgG decreased from 0.88 +/- 0.25 to 0.45 +/- 0.14 arbitrary units (P < 0.0001), becoming negative in 12 patients. Conclusions - Seropositivity for Cp- HSP60 appears to be a very sensitive and specific marker of ACS, unrelated to Cp IgG antibody titers or hs-CRP and TnT levels. Its causal involvement in instability and its diagnostic role in ACS deserve further study.
引用
收藏
页码:3015 / 3017
页数:3
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