Status of lipids, lipid peroxidation, and antioxidant systems with Vitamin C supplementation during aging in rats

被引：16

作者：

Jayachandran, M ^{[1
]}

Jayanthi, B ^{[1
]}

Sundaravadivel, B ^{[1
]}

Panneerselvam, C ^{[1
]}

机构：

[1] UNIV MADRAS,DEPT BIOCHEM MED,DR ALM POST GRAD INST BASIC MED SCI,MADRAS 600113,TAMIL NADU,INDIA

来源：

JOURNAL OF NUTRITIONAL BIOCHEMISTRY | 1996年 / 7卷 / 05期

关键词：

ascorbic acid; lipid peroxidation; antioxidants; aging;

D O I：

10.1016/0955-2863(96)00027-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Molecular mechanisms responsible for age-dependent deterioration of biochemical functions remain unclear. We determined the effect of ascorbic acid supplementation (20 mg/100 g body weight/day) in young and aged rats for 15, 30, and 60 days. In the aged animals cholesterol, triglycerides, phospholipids, and lipid peroxidation were considerably high, whereas, antioxidants superoxide dismutase, catalase, glutathione peroxidase, glutathione, ascorbic acid, and alpha-tocopherol were low. Administration of ascorbic acid reverted these age-associated differences to the status comparable to young rats.

引用

页码：270 / 275

页数：6

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