Cariostatic effects of a xylitol/NaF dentifrice in vivo

被引：15

作者：

Gaffar, A ^{[1
]}

Blake-Haskins, JC ^{[1
]}

Sullivan, R ^{[1
]}

Simone, A ^{[1
]}

Schmidt, R ^{[1
]}

Saunders, F ^{[1
]}

机构：

[1] Colgate Palmolive Technol Ctr, Morristown, NJ USA

来源：

INTERNATIONAL DENTAL JOURNAL | 1998年 / 48卷 / 01期

关键词：

D O I：

10.1111/j.1875-595X.1998.tb00691.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Xylitol has been shown to reduce plaque acids, but its topical cariostatic effect has been equivocal. The purpose of the studies reported here was to optimise the xylitol/NaF combination in dentifrices for an improved anticaries activity. In the first study, the combination of 10 per cent xylitol with 1100 ppm F (NaF), 1100 ppm F (NaF), and placebo dentifrices were tested in a rat caries model to assess the cariostatic effect. The combination was significantly more effective than fluoride by itself (P=0.05). The xylitol/NaF combination provided significantly more remineralisation of dentine than fluoride by itself. Collectively, results of these investigations confirm the improved anticaries effectiveness of the xylitol/NaF combination in a variety of animal and intra-oral models. A three-year clinical study confirmed these findings.

引用

页码：32 / 39

页数：8

共 18 条

[1] ENAMEL MICROHARDNESS CHANGE AND PLAQUE PH MEASUREMENTS IN AN INTRA-ORAL MODEL IN HUMANS [J].