Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human:: predominance of gec1/GABARAPL1 in the central nervous system

被引：50

作者：

Nemos, C ^{[1
]}

Mansuy, V ^{[1
]}

Vernier-Magnin, S ^{[1
]}

Fraichard, A ^{[1
]}

Jouvenot, M ^{[1
]}

Delage-Mourroux, R ^{[1
]}

机构：

[1] Univ Franche Comte, UFR Sci & Tech, Lab Biochim Biol Mol, F-25030 Besancon, France

来源：

MOLECULAR BRAIN RESEARCH | 2003年 / 119卷 / 02期

关键词：

gec1/GABAkAPL1; GABARAP; gene expression; macroarray; human; central nervous system;

D O I：

10.1016/j.molbrainres.2003.09.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons. Using specific cDNA probes, we investigated the differential expression of both genes in 76 human tissues. Against all odds, gec1/ GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：216 / 219

页数：4

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