Endocannabinoids mediate neuron-astrocyte communication

被引:436
作者
Navarrete, Marta [1 ]
Araque, Alfonso [1 ]
机构
[1] CSIC, Inst Cajal, E-28002 Madrid, Spain
关键词
D O I
10.1016/j.neuron.2008.01.029
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Cannabinoid receptors play key roles in brain function, and cannabinoid effects in brain physiology and drug-related behavior are thought to be mediated by receptors present in neurons. Neuron-astrocyte communication relies on the expression by astrocytes of neurotransmitter receptors. Yet, the expression of cannabinoid receptors by astrocytes in situ and their involvement in the neuron-astrocyte communication remain largely unknown. We show that hippocampal astrocytes express CB1 receptors that upon activation lead to phospholipase C-dependent Ca2+ mobilization from internal stores. These receptors are activated by endocannabinoids released by neurons, increasing astrocyte Ca2+ levels, which stimulate glutamate release that activates NMDA receptors in pyramidal neurons. These results demonstrate the existence of endocannabinoid-mediated neuron-astrocyte communication, revealing that astrocytes are targets of cannabinoids and might therefore participate in the physiology of cannabinoidrelated addiction. They also reveal the existence of an endocannabinoid-glutamate signaling pathway where astrocytes serve as a bridge for nonsynaptic interneuronal communication.
引用
收藏
页码:883 / 893
页数:11
相关论文
共 54 条
[31]   MOLECULAR CHARACTERIZATION OF A PERIPHERAL RECEPTOR FOR CANNABINOIDS [J].
MUNRO, S ;
THOMAS, KL ;
ABUSHAAR, M .
NATURE, 1993, 365 (6441) :61-65
[32]   New roles for astrocytes: Redefining the functional architecture of the brain [J].
Nedergaard, M ;
Ransom, B ;
Goldman, SA .
TRENDS IN NEUROSCIENCES, 2003, 26 (10) :523-530
[33]   Hippocampal astrocytes in situ exhibit calcium oscillations that occur independent of neuronal activity [J].
Nett, WJ ;
Oloff, SH ;
McCarthy, KD .
JOURNAL OF NEUROPHYSIOLOGY, 2002, 87 (01) :528-537
[34]   Cannabinoids enhance NMDA-elicited Ca2+ signals in cerebellar granule neurons in culture [J].
Netzeband, JG ;
Conroy, SM ;
Parsons, KL ;
Gruol, DL .
JOURNAL OF NEUROSCIENCE, 1999, 19 (20) :8765-8777
[35]   Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals [J].
Ohno-Shosaku, T ;
Maejima, T ;
Kano, M .
NEURON, 2001, 29 (03) :729-738
[36]   Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation [J].
Parri, HR ;
Gould, TM ;
Crunelli, V .
NATURE NEUROSCIENCE, 2001, 4 (08) :803-812
[37]  
Pasti L, 1997, J NEUROSCI, V17, P7817
[38]   Properties of synaptically evoked astrocyte calcium signal reveal synaptic information processing by astrocytes [J].
Perea, G ;
Araque, A .
JOURNAL OF NEUROSCIENCE, 2005, 25 (09) :2192-2203
[39]   Astrocytes potentiate transmitter release at single hippocampal synapses [J].
Perea, Gertrudis ;
Araque, Alfonso .
SCIENCE, 2007, 317 (5841) :1083-1086
[40]   The molecular logic of endocannabinoid signalling [J].
Piomelli, D .
NATURE REVIEWS NEUROSCIENCE, 2003, 4 (11) :873-884