Novel method for the synthesis of molecularly imprinted polymer bead libraries

被引：80

作者：

Kempe, H ^{[1
]}

Kempe, M ^{[1
]}

机构：

[1] Lund Univ, Biomed Ctr, Dept Cell & Mol Biol, Sect Cell & Matrix Biol, SE-22184 Lund, Sweden

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2004年 / 25卷 / 01期

关键词：

chemometrics; combinatorial library; molecular imprinting; spherical bead; suspension polymerization;

D O I：

10.1002/marc.200300189

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel method for the synthesis of spherical molecularly imprinted polymer (MIP) beads by suspension polymerization in mineral oil is described. The usefulness of the method was demonstrated by the synthesis of a propranolol imprinted MIP library. The composition of the library was generated by statistical experimental design. Multivariate data analysis correlated the screening data, obtained by a radioligand binding assay, to the composition of the MIPs.

引用

页码：315 / 320

页数：6

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