Macrophage fusion: the making of osteoclasts and giant cells

被引：162

作者：

Vignery, A ^{[1
]}

机构：

[1] Yale Univ, Sch Med, New Haven, CT 06510 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2005年 / 202卷 / 03期

关键词：

D O I：

10.1084/jem.20051123

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The fusion of cells is a fundamental biological event that is essential for a variety of developmental and homeostatic processes. Fusion is required for the formation of multinucleated osteoclasts and giant cells, although the mechanisms that govern these processes are poorly understood. A new study now reveals an unexpected role for the receptor, dendritic cell specific transmembrane protein (DC-STAMP), in this process. The potential mechanism by which DC-STAMP governs fusion and the implications of this finding will be discussed.

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页码：337 / 340

页数：4

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