Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration

被引：354

作者：

Park, Jin Woo ^{[1
,2
]}

Hwang, Seung Rim ^{[3
]}

Yoon, In-Soo ^{[4
]}

机构：

[1] Mokpo Natl Univ, Dept Pharm, Coll Pharm, Jeonnam 58554, South Korea

[2] Mokpo Natl Univ, Nat Med Res Inst, Jeonnam 58554, South Korea

[3] Chosun Univ, Coll Pharm, Dept Pharm, Gwangju 61452, South Korea

[4] Pusan Natl Univ, Coll Pharm, Busan 46241, South Korea

来源：

MOLECULES | 2017年 / 22卷 / 08期

关键词：

chronic wound; drug delivery system; growth factor; wound healing; PLATELET-RICH PLASMA; DIABETIC FOOT ULCERS; CULTURED ALLOGENIC KERATINOCYTES; EMERGING TREATMENT STRATEGIES; HYALURONIC-ACID; DRUG-DELIVERY; STEM-CELLS; FACTOR EGF; LIPID NANOPARTICLES; CLINICAL-EVALUATION;

D O I：

10.3390/molecules22081259

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Growth factors are endogenous signaling molecules that regulate cellular responses required for wound healing processes such as migration, proliferation, and differentiation. However, exogenous application of growth factors has limited effectiveness in clinical settings due to their low in vivo stability, restricted absorption through skin around wound lesions, elimination by exudation prior to reaching the wound area, and other unwanted side effects. Sophisticated systems to control the spatio-temporal delivery of growth factors are required for the effective and safe use of growth factors as regenerative treatments in clinical practice, such as biomaterial-based drug delivery systems (DDSs). The current review describes the roles of growth factors in wound healing, their clinical applications for the treatment of chronic wounds, and advances in growth factor-loaded DDSs for enhanced wound healing, focusing on micro-and nano-particulate systems, scaffolds, hydrogels, and other miscellaneous systems.

引用

页数：20

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