Improved autonomic neurocardial balance in short-term abstinent alcoholics treated with acamprosate

被引:12
作者
Agelink, MW [1 ]
Lemmer, W
Malessa, R
Zeit, T
Majewski, T
Klieser, E
机构
[1] Ruhr Univ Bochum, Evangelical Hosp Gelsenkirchen, Dept Psychiat, Bochum, Germany
[2] Ruhr Univ Bochum, Evangelical Hosp Gelsenkirchen, Dept Internal Med, Bochum, Germany
[3] Univ Jena, Dept Neurol, D-6900 Jena, Germany
来源
ALCOHOL AND ALCOHOLISM | 1998年 / 33卷 / 06期
关键词
D O I
10.1093/alcalc/33.6.602
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Standardized investigations on resting heart rate variability (HRV) should provide more information on acamprosate's human pharmacodynamic properties because acamprosate interacts with several neurotransmitter systems which are also involved in maintaining autonomic neurocardiac balance. We performed HRV measurements prospectively in 69 healthy controls and 19 chronic alcoholics to prove the hypotheses that: (1) compared to healthy controls, chronic alcoholics show disturbances in neurocardiac vagal function; and (2) in alcoholics, acamprosate treatment (6-8 days) should further decrease parasympathetic activity if acamprosate interacts with central gamma-aminobutyric acid(A) receptors in vivo. Cardiovagal dysfunction was initially present in 21% of the alcoholics. After treatment, however, their neurocardiac sympathetic-parasympathetic balance improved significantly.
引用
收藏
页码:602 / 605
页数:4
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